Smart brain pacemaker aims to stop seizures while you sleep

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-65 years of age * Diagnosis of Lennox-Gastaut Syndrome (LGS) with confirmed generalized seizures, including generalized tonic or tonic-clonic (GTC) seizures. Participants may also have complex partial, atypical absences or atonic seizures, but these will not count toward minimum seizure frequency eligibility. * Diagnosis is based on prior video EEG confirmation performed in the last 3 years. Scalp EEG showing slow spike-wave discharges and paroxysmal fast activity. * At least four seizures per month (GTC or tonic) on average during the three months preceding enrollment. * Medically intractable epilepsy, defined as failure to achieve acceptable seizure control despite trials of at least two antiseizure medications (ASMs). * Nonlocalized seizures, as determined by standard diagnostic studies. * Stable doses of two or more ASMs for at least one month prior to enrollment (rescue benzodiazepines for acute seizure clusters permitted). * Participants with vagus nerve stimulation (VNS) must have stable settings for at least two months prior to enrollment and throughout the study. * Subjective reporting of sleep disturbances. * Participant or legal guardian can provide informed consent and maintain an online seizure log, alone or with assistance. * Participant is willing to remain on a stable ASM regimen (except use of variable dose of rescue medications permitted) throughout the study and able to attend scheduled clinic visits. * Reliable caregiver is available to assist with seizure diary maintenance. Exclusion Criteria: * Predominant seizure type is focal-onset seizures. * Anatomical brain abnormalities precluding DBS implantation, or discrete brain lesions on MRI (e.g., cortical malformation, tuber, or sclerosis). * Unable to obtain brain MRI due to metal that is not compatible with 3T MRI. * History of psychogenic non-epileptic seizures or unstable psychiatric disorders, including suicidal ideation or intent within the last six months. * Clinically significant medical conditions increasing risk for pre- or postoperative complications (e.g., significant cardiac or pulmonary disease, uncontrolled hypertension). * Participant is pregnant or plans to become pregnant during the study. * Participation in another therapeutic investigational drug or device study. * Requirement for diathermy treatments during physical or occupational therapy. * In the opinion of the investigator or eligibility adjudication committee, the subject is unsuitable for the procedure.