Endocrine system disorder
MONDO:0005151A disease involving the endocrine system.
Also known as: disease of endocrine system, disease or disorder of endocrine system, disorder of endocrine system, endocrine disease, endocrine disorder, endocrine system disease, endocrine system disease or disorder, endocrine system disorder
12469 clinical trials for this condition and its sub-types, 78 tagged with Endocrine system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Endocrine system disorder
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Pancreas disorder 44 trials · 5,580 incl. sub-types
14 sub-types
- Endocrine pancreas disorder 1 trial · 3,923 incl. sub-types Sub-types →
- Pancreatic neoplasm 926 trials · 1,573 incl. sub-types Sub-types →
- Pancreatitis 120 trials · 203 incl. sub-types Sub-types →
- Exocrine pancreatic insufficiency 29 trials Sub-types →
- Recurrent acute pancreatitis 19 trials
- Accessory pancreas 0 trials
- Acinar cystic transformation of the pancreas 0 trials
- Annular pancreas 0 trials
- Congenital pancreatic cyst 0 trials
- Follicular cholangitis and pancreatitis 0 trials
- Lymphoepithelial cyst of the pancreas 0 trials
- Pancreatic mucinous ductal ectasia 0 trials
- Pancreatic steatorrhea 0 trials
- Pancreatic triacylglycerol lipase deficiency 0 trials Sub-types →
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Liver disorder 323 trials · 3,604 incl. sub-types
32 sub-types
- Liver and intrahepatic bile duct neoplasm 77 trials · 1,743 incl. sub-types Sub-types →
- Hepatitis 50 trials · 731 incl. sub-types Sub-types →
- Fatty liver disease 154 trials · 616 incl. sub-types Sub-types →
- Cirrhosis of liver 519 trials · 597 incl. sub-types Sub-types →
- Liver failure 71 trials · 197 incl. sub-types Sub-types →
- Hepatic vascular disorder 1 trial · 116 incl. sub-types Sub-types →
- Fibrotic liver disease 96 trials
- Alcoholic liver disease 44 trials · 85 incl. sub-types Sub-types →
- Drug-induced liver injury 21 trials · 23 incl. sub-types Sub-types →
- Hepatic porphyria 4 trials · 23 incl. sub-types Sub-types →
- Transient familial neonatal hyperbilirubinemia 18 trials
- Familial intrahepatic cholestasis 1 trial · 17 incl. sub-types Sub-types →
- Hepatorenal syndrome 13 trials
- Bile duct cyst 10 trials
- Liver abscess (disease) 4 trials
- Autosomal dominant polycystic liver disease 3 trials Sub-types →
- Cystic fibrosis-related liver disease 3 trials
- Intestinal failure–associated liver disease 3 trials
- Nodular regenerative hyperplasia of the liver 3 trials
- Glycogen storage disease due to liver phosphorylase kinase deficiency 0 trials · 2 incl. sub-types Sub-types →
- Aagenaes syndrome 1 trial
- Early-onset familial noncirrhotic portal hypertension 0 trials
- Hepatoportal sclerosis 0 trials
- Hepatopulmonary syndrome 0 trials
- Hyperbiliverdinemia 0 trials
- Idiopathic copper-associated cirrhosis 0 trials
- Liver disease, severe congenital 0 trials
- Membranous obstruction of inferior vena cava 0 trials
- Perinatal jaundice due to hepatocellular damage 0 trials
- Polycystic echinococcosis 0 trials
- Primitive portal vein thrombosis 0 trials
- Transient infantile hypertriglyceridemia and hepatosteatosis 0 trials
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Endocrine gland neoplasm 8 trials · 3,332 incl. sub-types
14 sub-types
- Malignant endocrine neoplasm 17 trials · 2,924 incl. sub-types Sub-types →
- Liver and intrahepatic bile duct neoplasm 77 trials · 1,743 incl. sub-types Sub-types →
- Neuroendocrine neoplasm 181 trials · 985 incl. sub-types Sub-types →
- Thyroid tumor 36 trials · 366 incl. sub-types Sub-types →
- Thymus neoplasm 5 trials · 240 incl. sub-types Sub-types →
- Adrenal gland neoplasm 13 trials · 151 incl. sub-types Sub-types →
- Pituitary tumor 23 trials · 83 incl. sub-types Sub-types →
- Benign endocrine neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Tumor of parathyroid gland 3 trials · 46 incl. sub-types Sub-types →
- Functioning endocrine neoplasm 0 trials · 38 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Non-functioning endocrine neoplasm 0 trials · 16 incl. sub-types Sub-types →
- Granulosa cell tumor 2 trials · 6 incl. sub-types Sub-types →
- Familial tumoral calcinosis 1 trial Sub-types →
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Gonadal disorder 3 trials · 1,635 incl. sub-types
6 sub-types
- Ovarian disorder 10 trials · 1,388 incl. sub-types Sub-types →
- Hypogonadism 47 trials · 163 incl. sub-types Sub-types →
- Testicular disorder 2 trials · 111 incl. sub-types Sub-types →
- Disorder of sexual differentiation 9 trials · 53 incl. sub-types Sub-types →
- Precocious puberty 18 trials · 19 incl. sub-types Sub-types →
- Gonadoblastoma 0 trials Sub-types →
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Autoimmune disorder of endocrine system 1 trial · 925 incl. sub-types
13 sub-types
- Type 1 diabetes mellitus 815 trials · 816 incl. sub-types Sub-types →
- Autoimmune thyroid disease 8 trials · 62 incl. sub-types Sub-types →
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Autoimmune polyendocrinopathy 3 trials · 11 incl. sub-types Sub-types →
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome 10 trials
- Autoimmune hypoparathyroidism 0 trials · 8 incl. sub-types Sub-types →
- Autoimmune pancreatitis 3 trials Sub-types →
- Autoimmune primary ovarian failure 1 trial
- IgG4-related sclerosing cholangitis 0 trials
- Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome 0 trials
- Autoimmune oophoritis 0 trials
- Insulin autoimmune syndrome 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Thyroid gland disorder 96 trials · 538 incl. sub-types
12 sub-types
- Thyroid tumor 36 trials · 366 incl. sub-types Sub-types →
- Goiter 12 trials · 102 incl. sub-types Sub-types →
- Hyperthyroidism 27 trials · 70 incl. sub-types Sub-types →
- Thyroiditis 1 trial · 62 incl. sub-types Sub-types →
- Hypothyroidism 48 trials · 60 incl. sub-types Sub-types →
- Inherited thyroid metabolism disease 0 trials · 8 incl. sub-types Sub-types →
- C-cell hyperplasia 0 trials
- Atrophy of thyroid 0 trials
- Euthyroid sick syndrome 0 trials
- Hyperthyroxinemia 0 trials Sub-types →
- Thyrocalcitonin secretion disease 0 trials
- Thyroid malformation 0 trials
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Adrenal gland disorder 9 trials · 352 incl. sub-types
18 sub-types
- Adrenal cortex disorder 0 trials · 185 incl. sub-types Sub-types →
- Adrenal gland neoplasm 13 trials · 151 incl. sub-types Sub-types →
- Adrenogenital syndrome 0 trials · 41 incl. sub-types Sub-types →
- Endogenous Cushing syndrome 3 trials · 38 incl. sub-types Sub-types →
- Pituitary dwarfism 38 trials Sub-types →
- Adrenoleukodystrophy 19 trials · 20 incl. sub-types Sub-types →
- Ectopic ACTH secretion syndrome 15 trials
- Autoimmune polyendocrine syndrome type 1 8 trials
- Primary pigmented nodular adrenocortical disease 2 trials Sub-types →
- Congenital adrenal insufficiency with 46, XY sex reversal OR 46,XY disorder of sex development-adrenal insufficiency due to CYP11A1 deficiency 1 trial
- Apparent mineralocorticoid excess 1 trial
- Hypoaldosteronism disease 1 trial Sub-types →
- Adrenal medullary hyperplasia 0 trials
- Adrenomyodystrophy 0 trials
- Corticosteroid-binding globulin deficiency 0 trials
- Isolated micronodular adrenocortical disease 0 trials
- Medulloadrenal hyperfunction 0 trials
- Pseudoleprechaunism syndrome, Patterson type 0 trials
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Thymus gland disorder 1 trial · 240 incl. sub-types
3 sub-types
- Thymus neoplasm 5 trials · 240 incl. sub-types Sub-types →
- Ectopic thymus 0 trials
- Thymic dysplasia 0 trials
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Polycystic ovary syndrome 200 trials
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Hereditary endocrine growth disease 26 trials · 195 incl. sub-types
8 sub-types
- Non-acquired pituitary hormone deficiency 0 trials · 84 incl. sub-types Sub-types →
- Inherited primary ovarian failure 2 trials · 47 incl. sub-types Sub-types →
- Congenital adrenal hyperplasia 36 trials · 38 incl. sub-types Sub-types →
- Growth hormone insensitivity syndrome 0 trials · 6 incl. sub-types Sub-types →
- Permanent congenital hypothyroidism 1 trial · 3 incl. sub-types Sub-types →
- Zerres Rietschel Majewski syndrome 0 trials
- Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome 0 trials
- Microdontia hypodontia short stature 0 trials
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Pituitary gland disorder 18 trials · 175 incl. sub-types
9 sub-types
- Pituitary tumor 23 trials · 83 incl. sub-types Sub-types →
- Anterior pituitary gland disorder 1 trial · 60 incl. sub-types Sub-types →
- Hypopituitarism 5 trials · 46 incl. sub-types Sub-types →
- Neurohypophyseal diabetes insipidus 9 trials
- Inappropriate ADH syndrome 5 trials
- Hypophysitis 2 trials Sub-types →
- Necrosis of pituitary 0 trials · 1 incl. sub-types Sub-types →
- Empty sella syndrome 0 trials
- Pituitary hypoplasia 0 trials
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Non-neoplastic bile duct disorder 0 trials · 172 incl. sub-types
5 sub-types
- Cholangitis 17 trials · 139 incl. sub-types Sub-types →
- Biliary atresia 24 trials Sub-types →
- Obstructive jaundice 11 trials
- Caroli disease 1 trial
- Extrahepatic cholestasis 0 trials Sub-types →
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Parathyroid gland disorder 14 trials · 164 incl. sub-types
4 sub-types
- Hyperparathyroidism 8 trials · 89 incl. sub-types Sub-types →
- Hypoparathyroidism 46 trials · 66 incl. sub-types Sub-types →
- Tumor of parathyroid gland 3 trials · 46 incl. sub-types Sub-types →
- Parathyroid hyperplasia 0 trials
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Beta thalassemia 73 trials · 99 incl. sub-types
3 sub-types
- Beta-thalassemia HBB/LCRB 2 trials · 57 incl. sub-types Sub-types →
- Dominant beta-thalassemia 0 trials
- Thalassemia, beta+, silent allele 0 trials
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Pituitary deficiency 0 trials · 96 incl. sub-types
5 sub-types
- Non-acquired pituitary hormone deficiency 0 trials · 84 incl. sub-types Sub-types →
- Central diabetes insipidus 5 trials · 12 incl. sub-types Sub-types →
- Acquired pituitary hormone deficiency 0 trials · 1 incl. sub-types Sub-types →
- Pituitary deficiency due to Rathke's pouch cysts 0 trials
- Pituitary deficiency due to empty sella turcica syndrome 0 trials
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Polyendocrinopathy 0 trials · 81 incl. sub-types
7 sub-types
- Multiple polyglandular tumor 0 trials · 62 incl. sub-types Sub-types →
- Autoimmune polyendocrinopathy 3 trials · 11 incl. sub-types Sub-types →
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome 10 trials
- Bangstad syndrome 0 trials
- Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome 0 trials
- Neuroectodermal-endocrine syndrome 0 trials
- Retinohepatoendocrinologic syndrome 0 trials
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Neuroendocrine disorder 0 trials · 42 incl. sub-types
4 sub-types
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Central diabetes insipidus 5 trials · 12 incl. sub-types Sub-types →
- Cyclic vomiting syndrome 8 trials
- Posterior pituitary gland neoplasm 0 trials Sub-types →
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Hyperinsulinemic hypoglycemia 2 trials · 14 incl. sub-types
5 sub-types
- Familial hyperinsulinism 9 trials · 12 incl. sub-types Sub-types →
- Hyperinsulinemic hypoglycemia, familial, 1 1 trial Sub-types →
- Hyperinsulinemic hypoglycemia with polycystic kidney disease 0 trials
- Hyperinsulinemic hypoglycemia, familial, 8 0 trials
- Insulin autoimmune syndrome 0 trials
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Parneoplastic endocrine syndrome 0 trials · 11 incl. sub-types
2 sub-types
- POEMS syndrome 8 trials
- Oncogenic osteomalacia 3 trials
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Inherited obesity 8 trials · 9 incl. sub-types
7 sub-types
- Obesity due to pro-opiomelanocortin deficiency 2 trials
- Obesity due to congenital leptin deficiency 1 trial
- Obesity due to leptin receptor gene deficiency 1 trial
- Obesity due to prohormone convertase I deficiency 1 trial
- Obesity due to CEP19 deficiency 0 trials
- Obesity due to SIM1 deficiency 0 trials
- Obesity due to melanocortin 4 receptor deficiency 0 trials
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Acquired hypothalamic obesity 7 trials
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Disorder of GNAS inactivation 0 trials · 7 incl. sub-types
5 sub-types
- Pseudohypoparathyroidism type 1A 7 trials
- Pseudopseudohypoparathyroidism 2 trials
- Progressive osseous heteroplasia 0 trials
- Pseudohypoparathyroidism type 1B 0 trials
- Pseudohypoparathyroidism type 1C 0 trials
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Disorders of vitamin D metabolism 0 trials · 3 incl. sub-types
1 sub-type
- Hypocalcemic rickets 0 trials · 3 incl. sub-types Sub-types →
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NKX2-1 related choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 0 trials · 1 incl. sub-types
3 sub-types
- Thyroid cancer, nonmedullary, 1 1 trial
- Brain-lung-thyroid syndrome 0 trials
- Hereditary progressive chorea without dementia 0 trials
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Familial hypocalciuric hypercalcemia 0 trials · 1 incl. sub-types
3 sub-types
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17,20-lyase deficiency, isolated 0 trials
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Bamforth-Lazarus syndrome 0 trials
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Leydig cell hypoplasia 0 trials
2 sub-types
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Wolfram-like syndrome 0 trials
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Campomelic dysplasia 0 trials
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Diencephalic syndrome 0 trials
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Duplication of the pituitary gland 0 trials
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Endocrine tuberculosis 0 trials
1 sub-type
- Hepatic tuberculosis 0 trials
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Estrogen resistance syndrome 0 trials
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Genito-palato-cardiac syndrome 0 trials
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Neonatal iodine exposure 0 trials
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Thyroid hormone metabolism, abnormal 0 trials
3 sub-types
- Thyroid hormone metabolism, abnormal 1 0 trials
- Thyroid hormone metabolism, abnormal, 2 0 trials
- Thyroid hormone metabolism, abnormal, 3 0 trials
Most studied deeper sub-types
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New weekly shot could help diabetics shed pounds
Disease control OngoingThis Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…
Phase 3 • Sponsor: Pfizer • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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New weekly shot could help diabetics with kidney trouble control blood sugar
Disease control OngoingThis study tests a once-weekly injection called retatrutide in 320 adults with type 2 diabetes and moderate to severe kidney disease who are not controlling their blood sugar well on insulin. Participants will receive either the drug or a placebo for about 14 months. The goal is …
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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New obesity drug CRB-913 enters human testing
Disease control OngoingThis study tests a new drug called CRB-913 for weight loss in people with obesity. It involves 252 participants and has two parts: first, measuring how the drug works in healthy adults, then comparing three doses against a placebo over 12 weeks. The goal is to check safety and ho…
Phase 1 • Sponsor: Corbus Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New pill shows promise against Hard-to-Treat RET-Driven cancers
Disease control OngoingThis study tests an oral drug called selpercatinib in people with advanced solid tumors that have RET gene alterations, including certain lung, thyroid, and colon cancers. The goal is to find the best dose and see if the drug can shrink tumors. About 857 participants are enrolled…
Phase 1/2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New diabetes drug retatrutide takes on semaglutide in major trial
Disease control OngoingThis study tests a new weekly medicine, retatrutide, against an existing one, semaglutide, in about 1250 adults with type 2 diabetes whose blood sugar is not well controlled by metformin. The goal is to see which works better at lowering blood sugar and weight over 26 months. Par…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Stem cell shot into ovaries aims to tame perimenopause symptoms
Disease control By invitation onlyThis study looks at whether injecting special stem-like cells called Muse cells directly into the ovaries can help women aged 28 to 70 who are in perimenopause. The cells may repair tissue, reduce inflammation, and improve hormone balance. Researchers will track safety, hormone l…
Sponsor: Healing Hope International • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Could a higher dose of tirzepatide tackle diabetes and obesity together?
Disease control OngoingThis phase 2 trial tests different doses of tirzepatide in 414 adults with type 2 diabetes and obesity who already take metformin. The goal is to see if the drug helps with weight loss and blood sugar control. Participants receive either tirzepatide or a placebo for about 89 week…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New shot could help diabetics shed pounds on top of existing meds
Disease control OngoingThis Phase 2 study tests an experimental drug called AZD6234, given as a weekly injection, for weight loss in adults with overweight or obesity and type 2 diabetes. Participants are already on a stable dose of a GLP-1 medication. The study will compare AZD6234 to a placebo over 2…
Phase 2 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New oral drug shows promise for kids with rare RET-Driven cancers
Disease control OngoingThis study tests an oral drug called selpercatinib (LOXO-292) in children with advanced solid or brain tumors that have a specific RET gene change. The trial has two parts: first finding a safe dose, then measuring how many children's tumors shrink. About 36 children whose cancer…
Phase 1/2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Could a gut procedure help control diabetes? new trial investigates
Disease control PausedThis study tests a procedure called duodenal mucosal resurfacing (DMR) using the Revita system in people with type 2 diabetes whose blood sugar is not well controlled with medication. About 320 adults will be randomly assigned to receive either the real procedure or a sham (fake)…
Sponsor: Fractyl Health Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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New cell implant aims to curb severe low blood sugar in type 1 diabetes
Disease control CancelledThis study tested a new treatment called SR-02, which involves implanting insulin-producing cells into the abdomen of adults with type 1 diabetes who experience dangerously low blood sugar. Participants would need to take lifelong anti-rejection drugs to prevent the body from att…
Phase 1/2 • Sponsor: Seraxis • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New drug could free patients from daily calcium pills
Disease control OngoingThis phase 3 trial tests eneboparatide, a lab-made hormone, in 165 adults with chronic hypoparathyroidism. The goal is to see if it can help patients stop taking high-dose calcium and vitamin D supplements while keeping calcium levels normal. Participants receive either the drug …
Phase 3 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Can a smartphone app lift the emotional burden of type 2 diabetes?
Symptom relief OngoingThis study tests a self-guided digital program called covivio to help adults with type 2 diabetes manage emotional distress tied to their condition. About 250 participants will either use the app alongside their usual care or continue with usual care alone. The goal is to see if …
Sponsor: Gaia AG • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Sleep your way to more steps? new study tests the idea
Knowledge-focused OngoingThis study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Wearable tech puts hormone health to the test
Knowledge-focused OngoingThis trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…
Sponsor: Felix Beuschlein • Aim: Knowledge-focused
Last updated Jul 29, 2026 00:00 UTC
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Gastric bypass secrets: intestine rewires metabolism
Knowledge-focused OngoingThis study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Brain scans reveal hidden links between body diseases and metabolism
Knowledge-focused OngoingThis study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…
Sponsor: The First Affiliated Hospital of Zhengzhou University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC