Endocarditis

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested whether stable patients with a serious heart valve infection (endocarditis) could safely switch from intravenous (IV) antibiotics to oral amoxicillin pills. Over 300 adults participated. The goal was to see if the oral switch worked as well as continuing IV trea…

This study tested whether patients with a serious heart valve infection (endocarditis) caused by staph bacteria could safely switch from intravenous (IV) antibiotics to oral pills after at least 10 days of IV treatment. The trial involved 162 adults with left-sided endocarditis. …

This study tested a device called HA-380® that filters inflammatory substances from the blood during heart-lung bypass in complex cardiac surgeries. Forty-one adults undergoing high-risk procedures like heart transplants or aortic dissection repairs were enrolled. The goal was to…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study is testing whether a special PET/CT scan using gallium-68 citrate can more accurately diagnose infections in artificial heart valves. Researchers will compare the scan results with the standard diagnosis after 3 months. The study involves 40 adults with suspected valve…

This study tested whether a special PET-CT scan using a radioactive tracer (18F-FDG) can improve diagnosis of infectious endocarditis on natural heart valves. Researchers scanned 31 adults with suspected endocarditis within 5 days of starting care. The goal was to see how well th…

This study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…

This study looked back at the medical records of 140 adults who had surgery for a serious heart infection called infective endocarditis. The goal was to see how many patients survived 30 days after surgery and what factors might lead to complications. Researchers also checked if …

This study involved 30 patients who had a transcatheter aortic valve replacement (TAVR). Researchers used a special PET/CT scan with a radioactive tracer to see how noninfected valves appear on imaging. The goal is to create a baseline pattern so doctors can better tell if a valv…

This study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…

This study looked at the bacteria living on the skin of 100 patients scheduled for a heart valve replacement procedure called TAVI. The goal was to find out which bacteria are most common in the groin area, where the doctor inserts the new valve. This information can help doctors…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find which toxins (harmful substances) the bacteria produce that lead to serious illnesses like blood infections or heart valve infections. Researchers compared samples from patients with differen…

This completed study looked at 209 patients with bacterial endocarditis, a serious heart valve infection, to understand how common anemia is and what causes it. Researchers measured blood markers for inflammation and anemia from diagnosis up to 6 months after hospital discharge. …