Dystonic disorder

This study tests whether changing the way deep brain stimulation is delivered can improve tremor control in people with essential tremor who don't get enough relief from their current settings. Researchers will use computer models and brain scans to see how the new stimulation pa…

This pilot trial tested whether taking oral zinc every day for 6 months is safe and doable for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. 13 participants aged 6 months to 30 years took zinc acetate. The…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested an experimental pill called dipraglurant in 15 people with blepharospasm, a condition causing uncontrollable eyelid spasms. Participants received either 50 mg, 100 mg, or a placebo to see if the drug is safe and can reduce spasm severity and frequency. The goal …

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study used PET and MRI brain scans to measure how a brain chemical called acetylcholine works in people with dystonia, a condition that causes involuntary muscle twisting. Researchers compared 31 adults with cervical or DYT1 dystonia to healthy volunteers. The goal was to be…

This study tests a device that synchronizes two types of brain stimulation — deep brain stimulation (DBS) and transcranial alternating current stimulation (tACS) — in people with Parkinson's disease. Only 2 participants will be enrolled to see if the device can lock the timing of…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study looked at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants received either an alcoholic drink or a non-alcoholic placebo on separate days. Researchers measured tremor changes using a motion sensor and clini…

This study looked at how a specific brain chemical system (cholinergic) might be involved in dystonia, a condition causing muscle spasms and abnormal postures. Researchers used PET scans to measure chemical activity in the brains of 40 adults with a genetic form of dystonia (DYT1…

This study looked at 102 adults with dystonia, a condition causing involuntary muscle contractions. Researchers used questionnaires and brain wave recordings to assess memory, attention, mood, and decision-making. The goal was to better understand the non-motor symptoms of dyston…

This study tested how accurately a robot system called Neurolocate helps place electrodes in the brain during deep brain stimulation surgery. It involved 18 adults with Parkinson's disease, dystonia, or tremor. The goal was to see if the robot could improve precision, reduce surg…

This study looked at how people with cervical or myoclonus dystonia perceive their own actions, known as the 'sense of agency.' Researchers used computer tasks and brain scans to measure how accurately participants felt in control of their movements. The goal was to link these fe…

This study looked at how two brain regions—the cerebellum and striatum—communicate in people with dystonia caused by ADCY5 or PRRT2 gene mutations. Researchers used MRI scans and mild brain stimulation to compare brain activity among patients and healthy volunteers. The goal was …

This completed study tested deep brain stimulation (DBS) in the cerebellum's dentate nucleus to treat movement disorders like tremor, dystonia, and ataxia. Researchers used advanced MRI and electrical recordings to guide electrode placement in 20 adults. The goal was to see if th…

This completed study used eye-tracking to explore how the brain adapts movements in people with dystonia, essential tremor, or Parkinson disease. Researchers measured eye movements before and after a task to look for signs of cerebellar dysfunction. The study included 14 particip…

This study investigates how the cerebellum influences brain plasticity in people with dystonia, a movement disorder, and in healthy volunteers. Researchers use non-invasive brain stimulation (TMS) to temporarily change cerebellar activity and measure its effects on brain plastici…