Dyspepsia

Upper abdominal pain often comes from functional dyspepsia, irritable bowel syndrome, or uncomplicated gallstones. These conditions overlap and many patients do not know that tests and surgery may not help. Researchers are testing a personalized web-based education tool that expl…

This trial tests whether a daily fibre supplement, taken for 8 weeks, can improve gut health and ease symptoms like bloating, indigestion, and irregular bowel movements. Fifty adults who experience digestive discomfort will take the supplement each morning and answer questionnair…

This study tests two different drug combinations to treat Helicobacter pylori, a stomach bacteria that can cause indigestion. About 66 adults with dyspepsia will receive either a triple therapy (amoxicillin, clarithromycin, esomeprazole) or a quadruple therapy (bismuth, metronida…

This study is testing a new device called Gastric Alimetry that records the stomach's electrical activity through electrodes placed on the belly. Researchers want to see if it can reliably detect abnormal stomach rhythms in people with conditions like gastroparesis and functional…

This study tests a drug called tradipitant for people with functional dyspepsia, a condition causing stomach pain and fullness after eating. Researchers will compare the drug to a placebo in 60 adults to see if it improves stomach function and reduces symptoms. The goal is to fin…

This study tests whether a small device worn behind the ear, which sends mild electrical pulses to nerves, can reduce abdominal pain in adults with gastroparesis-like symptoms (slow stomach emptying). About 140 participants will be randomly assigned to receive either the active d…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This study looks at 200 people with ongoing stomach discomfort (functional dyspepsia) to find out how often they have small intestinal bacterial overgrowth (SIBO). Researchers will compare two methods—growing bacteria in a lab and DNA testing—to identify which germs are present. …

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This study follows 2,500 people with gastroesophageal reflux disease (GERD) to compare how well medications and surgery work over time. Researchers will track quality of life, heartburn symptoms, and patient satisfaction. The goal is to identify who benefits most from each treatm…