Digestive system disorder
MONDO:0004335A disease or disorder that involves the digestive system.
Also known as: digestive disease, digestive system disease, digestive system disease or disorder, digestive system disorder, disease of digestive system, disease or disorder of digestive system, disorder of digestive system, gastroenterological system disease
16300 clinical trials for this condition and its sub-types, 168 tagged with Digestive system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system disorder
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Digestive system cancer 267 trials · 7,054 incl. sub-types
15 sub-types
- Digestive system carcinoma 25 trials · 4,876 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,786 incl. sub-types Sub-types →
- Liver cancer 254 trials · 1,700 incl. sub-types Sub-types →
- Malignant pancreatic neoplasm 899 trials · 1,444 incl. sub-types Sub-types →
- Gastric cancer 724 trials · 1,034 incl. sub-types Sub-types →
- Esophageal cancer 408 trials · 787 incl. sub-types Sub-types →
- Pharynx cancer 10 trials · 495 incl. sub-types Sub-types →
- Oral cavity cancer 42 trials · 288 incl. sub-types Sub-types →
- Gastroesophageal cancer 157 trials
- Gallbladder cancer 73 trials · 106 incl. sub-types Sub-types →
- Gastrointestinal lymphoma 0 trials · 7 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Digestive system melanoma 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Spleen cancer 0 trials · 2 incl. sub-types Sub-types →
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Pancreas disorder 44 trials · 5,580 incl. sub-types
14 sub-types
- Endocrine pancreas disorder 1 trial · 3,923 incl. sub-types Sub-types →
- Pancreatic neoplasm 926 trials · 1,573 incl. sub-types Sub-types →
- Pancreatitis 120 trials · 203 incl. sub-types Sub-types →
- Exocrine pancreatic insufficiency 29 trials Sub-types →
- Recurrent acute pancreatitis 19 trials
- Accessory pancreas 0 trials
- Acinar cystic transformation of the pancreas 0 trials
- Annular pancreas 0 trials
- Congenital pancreatic cyst 0 trials
- Follicular cholangitis and pancreatitis 0 trials
- Lymphoepithelial cyst of the pancreas 0 trials
- Pancreatic mucinous ductal ectasia 0 trials
- Pancreatic steatorrhea 0 trials
- Pancreatic triacylglycerol lipase deficiency 0 trials Sub-types →
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Intestinal disorder 70 trials · 5,432 incl. sub-types
58 sub-types
- Large intestine disorder 2 trials · 3,811 incl. sub-types Sub-types →
- Intestinal neoplasm 4 trials · 3,074 incl. sub-types Sub-types →
- Inflammatory bowel disease 429 trials · 1,079 incl. sub-types Sub-types →
- Gastroenteritis 20 trials · 837 incl. sub-types Sub-types →
- Small intestine disorder 7 trials · 385 incl. sub-types Sub-types →
- Irritable bowel syndrome 221 trials
- Bowel dysfunction 11 trials · 210 incl. sub-types Sub-types →
- Glucose-galactose malabsorption 2 trials · 151 incl. sub-types Sub-types →
- Malabsorption syndrome 13 trials · 118 incl. sub-types Sub-types →
- Intestinal obstruction 44 trials · 91 incl. sub-types Sub-types →
- Eosinophilic gastrointestinal disease 9 trials · 73 incl. sub-types Sub-types →
- Intestinal fistula 6 trials · 63 incl. sub-types Sub-types →
- Necrotizing enterocolitis 51 trials Sub-types →
- Intestinal motility disease 10 trials · 39 incl. sub-types Sub-types →
- Short bowel syndrome 39 trials Sub-types →
- Diverticulitis 28 trials · 34 incl. sub-types Sub-types →
- Chronic intestinal failure 24 trials
- Neurogenic bowel 22 trials
- Postgastrectomy syndrome 2 trials · 20 incl. sub-types Sub-types →
- Hypertrophic pyloric stenosis 16 trials Sub-types →
- Parasitic intestinal disorder 0 trials · 16 incl. sub-types Sub-types →
- Ischemic bowel disorder 8 trials · 15 incl. sub-types Sub-types →
- Endometriosis of intestine 9 trials
- Intestinal perforation 9 trials Sub-types →
- Intestinal polyp 8 trials
- Protein-losing enteropathy 7 trials
- Intestinal atresia 3 trials · 6 incl. sub-types Sub-types →
- Chronic intestinal vascular insufficiency 4 trials
- Refractory celiac disease 4 trials
- Volvulus of midgut 4 trials Sub-types →
- Abetalipoproteinemia 2 trials
- Pneumatosis cystoides intestinalis 2 trials
- Angiodysplasia of intestine 1 trial
- Chronic enteropathy associated with SLCO2A1 gene 1 trial
- Cryptogenic multifocal ulcerous stenosing enteritis 1 trial
- Steatorrhea 1 trial Sub-types →
- 4-hydroxyphenylacetic aciduria 0 trials
- Aeromonas hydrophila intestinal disease 0 trials
- NK-cell enteropathy 0 trials
- Satoyoshi syndrome 0 trials
- Whipple disease 0 trials
- Aplasia cutis congenita-intestinal lymphangiectasia syndrome 0 trials
- Chronic atrial and intestinal dysrhythmia 0 trials
- Chronic diarrhea with villous atrophy 0 trials
- Collagenous sprue 0 trials
- Congenital diarrhea 7 with exudative enteropathy 0 trials
- Congenital enterocyte heparan sulfate deficiency 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Intestinal dysmotility syndrome 0 trials
- Intestinal lymphangiectasia 0 trials Sub-types →
- Intractable diarrhea-choanal atresia-eye anomalies syndrome 0 trials
- Isolated mesenteric vein thrombosis 0 trials
- Malakoplakia 0 trials
- Mucocele of appendix 0 trials
- Primary desmosis coli 0 trials
- Solitary rectal ulcer syndrome 0 trials
- Trichohepatoenteric syndrome 0 trials Sub-types →
- Visceral leiomyopathy, African degenerative 0 trials
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Hepatobiliary disorder 10 trials · 3,893 incl. sub-types
4 sub-types
- Liver disorder 323 trials · 3,604 incl. sub-types Sub-types →
- Hepatobiliary neoplasm 26 trials · 1,772 incl. sub-types Sub-types →
- Biliary tract disorder 22 trials · 1,001 incl. sub-types Sub-types →
- Gallbladder disorder 26 trials · 219 incl. sub-types Sub-types →
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Stomach disorder 4 trials · 1,623 incl. sub-types
19 sub-types
- Gastric neoplasm 685 trials · 1,101 incl. sub-types Sub-types →
- Gastroesophageal reflux disease 217 trials Sub-types →
- Functional gastric disease 47 trials · 213 incl. sub-types Sub-types →
- Gastritis 21 trials · 50 incl. sub-types Sub-types →
- Hiatus hernia 49 trials Sub-types →
- Pyloric stenosis 15 trials · 31 incl. sub-types Sub-types →
- Gastric intestinal metaplasia 18 trials
- Gastric ulcer 13 trials Sub-types →
- Stomach polyp 4 trials · 6 incl. sub-types Sub-types →
- Gastric dilatation 3 trials
- Achlorhydria 1 trial
- Pylorospasm 1 trial
- Dieulafoy lesion 0 trials
- Angiodysplasia of stomach 0 trials
- Cascade stomach 0 trials
- Gastric duplication 0 trials
- Non-hypoproteinemic hypertrophic gastropathy 0 trials
- Pyloric duplication 0 trials
- Stomach diverticulosis 0 trials
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Upper digestive tract disorder 6 trials · 1,226 incl. sub-types
2 sub-types
- Esophageal disorder 20 trials · 1,221 incl. sub-types Sub-types →
- Internal hirudiniasis 0 trials
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Autoimmune disorder of gastrointestinal tract 0 trials · 936 incl. sub-types
7 sub-types
- Type 1 diabetes mellitus 815 trials · 816 incl. sub-types Sub-types →
- Celiac disease 79 trials Sub-types →
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Autoimmune enteropathy 2 trials · 11 incl. sub-types Sub-types →
- Autoimmune gastritis 3 trials
- Autoimmune pancreatitis 3 trials Sub-types →
- IgG4-related sclerosing cholangitis 0 trials
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Digestive system infectious disorder 4 trials · 605 incl. sub-types
22 sub-types
- Viral hepatitis 12 trials · 443 incl. sub-types Sub-types →
- Infectious colitis 0 trials · 69 incl. sub-types Sub-types →
- Intestinal infectious disease 3 trials · 49 incl. sub-types Sub-types →
- Small intestinal bacterial overgrowth 18 trials
- Parasitic intestinal disorder 0 trials · 16 incl. sub-types Sub-types →
- Liver abscess (disease) 4 trials
- Campylobacteriosis 3 trials Sub-types →
- Bacterial gastritis 2 trials
- Gastrointestinal tuberculosis 0 trials · 2 incl. sub-types Sub-types →
- Aeromonas hydrophila intestinal disease 0 trials
- Salmonella gastroenteritis 0 trials
- Whipple disease 0 trials
- Anal verrucous carcinoma 0 trials
- Bacterial esophagitis 0 trials
- Colorectal Kaposi sarcoma 0 trials Sub-types →
- Fungal esophagitis 0 trials Sub-types →
- Fungal gastritis 0 trials
- Internal hirudiniasis 0 trials
- Oropharyngeal anthrax 0 trials
- Polycystic echinococcosis 0 trials
- Viral esophagitis 0 trials
- Viral gastritis 0 trials Sub-types →
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Neoplasm of oropharynx 3 trials · 279 incl. sub-types
2 sub-types
- Oropharynx cancer 149 trials · 279 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
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Digestive system neuroendocrine neoplasm 52 trials · 167 incl. sub-types
7 sub-types
- Digestive system neuroendocrine tumor, grade 1/2 66 trials · 145 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Gallbladder neuroendocrine neoplasm 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Diarrheal disease 80 trials · 117 incl. sub-types
7 sub-types
- Acute diarrhea 10 trials · 42 incl. sub-types Sub-types →
- Inflammatory diarrhea 0 trials · 33 incl. sub-types Sub-types →
- Chronic diarrheal disease 10 trials Sub-types →
- Congenital diarrhea 0 trials · 5 incl. sub-types Sub-types →
- Secretory diarrhea 0 trials · 5 incl. sub-types Sub-types →
- Diarrheal disease secondary to altered bowel motility 0 trials Sub-types →
- Non-infectious diarrheal disease 0 trials Sub-types →
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Peptic ulcer disease 26 trials · 67 incl. sub-types
6 sub-types
- Peptic esophagitis 24 trials
- Gastric ulcer 13 trials Sub-types →
- Duodenal ulcer 7 trials
- Gastrojejunal ulcer 6 trials
- Active peptic ulcer disease 3 trials
- Peptic ulcer perforation 3 trials
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Gastrointestinal mucositis 3 trials · 52 incl. sub-types
2 sub-types
- Intestinal infectious disease 3 trials · 49 incl. sub-types Sub-types →
- Inflammatory diarrhea 0 trials · 33 incl. sub-types Sub-types →
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Benign digestive system neoplasm 0 trials · 41 incl. sub-types
10 sub-types
- Pleomorphic adenoma 12 trials
- Hepatobiliary benign neoplasm 2 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Hepatocellular adenoma 2 trials Sub-types →
- Benign neoplasm of gallbladder 0 trials Sub-types →
- Benign neoplasm of oropharynx 0 trials
- Bile duct papillary neoplasm 0 trials Sub-types →
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Hereditary mixed polyposis syndrome 5 trials · 6 incl. sub-types
2 sub-types
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Juvenile polyposis syndrome 5 trials
3 sub-types
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Gastrointestinal polyp 0 trials · 3 incl. sub-types
2 sub-types
- Gastrointestinal hamartoma 0 trials · 3 incl. sub-types Sub-types →
- Anal polyp 0 trials Sub-types →
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Cronkhite-Canada syndrome 1 trial
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Hyperplastic polyposis syndrome 1 trial
2 sub-types
- Colon serrated polyposis 1 trial
- Sessile serrated polyposis cancer syndrome 0 trials
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Meckel diverticulum 0 trials
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Caudal duplication 0 trials
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Common mesentery 0 trials
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Congenital peritoneal encapsulation 0 trials
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Digestive duplication 0 trials
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Diverticulosis, small-intestinal 0 trials
Most studied deeper sub-types
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Poop pills for tummy troubles? new trial tests FMT in kids
Disease control Stopped earlyThis study is testing whether fecal microbiota transplantation (FMT) can help children with functional gastrointestinal disorders (FGIDs) – chronic gut issues without a clear physical cause. Researchers will give 100 children either FMT or standard drugs and track changes in symp…
Phase 3 • Sponsor: Biao Zou • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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New hope for ulcerative colitis? drug trial shows promise
Disease control Stopped earlyThis study tested a drug called vixarelimab in 79 people with moderate to severe ulcerative colitis (UC) who had not responded well to other treatments. The goal was to see if the drug could help control the disease and reduce symptoms like diarrhea and bleeding. The study was st…
Phase 2 • Sponsor: Genentech, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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A tiny dose of an old drug might stop Post-Surgery brain fog in seniors
Prevention Stopped earlyThis trial tests whether a single low dose of droperidol, given just before the end of surgery, can prevent postoperative delirium—a state of confusion and disorientation—in adults aged 65 and older undergoing non-cardiac surgery. About 800 participants will receive either droper…
Sponsor: RenJi Hospital • Aim: Prevention
Last updated Aug 14, 2026 00:00 UTC
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Enzyme cocktails aim to soothe tummy troubles
Symptom relief Stopped earlyThis study looked at whether two enzyme blends can safely ease mild to moderate stomach discomfort in healthy adults. Eighteen participants took a placebo for 4 weeks and the enzyme for 4 weeks, filling out weekly questionnaires about their gut health. The goal was to see if the …
Sponsor: The Archer-Daniels-Midland Company • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC