Diabetic polyneuropathy

This trial tests whether a traditional Chinese herbal formula, Zuogui Jiangtang Shuluo, can improve nerve function and reduce symptoms in people with diabetic peripheral neuropathy, a common complication of type 2 diabetes that causes pain, numbness, and tingling. Participants wi…

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This trial investigates whether tirzepatide, a medication already used for diabetes and weight loss, can help repair nerve damage in people with diabetic peripheral neuropathy. The study includes 40 adults with diabetes and nerve pain or numbness. Researchers will measure nerve h…

This study compares two exercise programs—combined aerobic and resistance training versus seated soleus push-ups—against standard care in people with type 2 diabetes and diabetic peripheral neuropathy. Researchers will measure blood markers of nerve repair (BDNF, NGF, S100B) and …

This study looks at how well nerve tests and ultrasound can detect diabetic peripheral neuropathy, a common complication of diabetes that causes pain and numbness in the feet. Researchers will compare results from 75 adults with diabetes and healthy volunteers to see which tests …

This trial tests whether a lower dose of duloxetine combined with alpha-lipoic acid can relieve painful diabetic peripheral neuropathy as effectively as the standard higher dose of duloxetine alone. Adults with diabetes and nerve pain will be randomly assigned to one of the two t…

This study tests whether acupressure—a non-invasive therapy using finger pressure on specific body points—can reduce nerve pain, improve balance confidence, and lessen fear of falling in adults aged 65+ with painful diabetic peripheral neuropathy. 76 participants will be randomly…

This study tests whether low-frequency electroacupuncture can reduce pain and numbness in people with diabetic peripheral neuropathy (DPN). 92 adults with DPN will receive either real or sham electroacupuncture for 6 weeks. Researchers will measure nerve function, pain levels, an…

This study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…

This study tests an injectable supplement that combines B vitamins with an energy molecule (ATP) to treat painful diabetic nerve damage. Two hundred adults with diabetes and nerve pain will receive either the ATP-enhanced shot or a standard B vitamin shot for 12 weeks. Researcher…

This study investigates whether blood levels of irisin, a protein linked to glucose metabolism and nerve protection, differ in people with type 2 diabetes who have diabetic polyneuropathy (nerve damage) compared to those without it and healthy controls. Researchers will measure i…

This study looks at whether a painless ultrasound scan of the sciatic nerve and a blood test for a specific protein can help detect diabetic peripheral neuropathy (nerve damage) earlier than current methods. Researchers will measure nerve size and blood flow in 120 people with ty…

This study will analyze blood samples from 90 people — 30 healthy, 30 with diabetes but no nerve issues, and 30 with diabetic peripheral neuropathy (nerve damage causing pain). Researchers will look for unique molecules in the blood that could serve as early warning signs. The go…

This study looks at how diabetic polyneuropathy (nerve damage from diabetes) changes responses to common dental pulp tests like electric and cold stimuli. Researchers will compare people with mild neuropathy, severe neuropathy, and healthy controls to see if nerve damage leads to…