COPD, severe early onset

This phase 3 trial tests whether a fixed-dose combination inhaler containing tiotropium and salmeterol works better than either drug alone or placebo for people with chronic obstructive pulmonary disease (COPD). The study measures improvements in lung function, shortness of breat…

This study tested a high-flow nasal cannula device (Airvo) in COPD patients with high carbon dioxide levels who could not or would not use standard non-invasive ventilation. The goal was to see if the device improved blood gas levels and reduced flare-ups over one year. Only 3 pa…

This study tested whether a low dose of fentanyl, a strong painkiller, placed under the tongue could help people with severe COPD feel less breathless during exercise. The trial planned to include 40 participants but was stopped early. Because it was terminated, we cannot draw cl…

This phase 2 pilot study tested a new dual bronchodilator inhaler called PT003 in 4 people with stable moderate-to-severe COPD. Researchers measured breathing patterns and lung function right after the first dose and again after 4 weeks of treatment. The goal was to see if PT003 …

This study looked at whether a gentle electrical stimulation device (TENS) placed on the skin could help people with COPD exercise longer after a serious flare-up. The plan was to compare exercise time with and without TENS in a small group of patients. However, the study was sto…

This pilot study explored whether adding acupuncture to standard pulmonary rehabilitation can improve lung function, exercise tolerance, and quality of life in people with COPD. Thirteen adults took part, receiving either electro-acupuncture at specific points or a control acupun…

Researchers are studying adults with COPD who go to the emergency room or day hospital for sudden worsening of their breathing. The study checks how many of these patients test positive for respiratory syncytial virus (RSV) during the RSV season, from October to April. They compa…

This trial tests two new devices, NivolisMonitor and NivolisAnton, designed for people who use breathing support at home, such as non-invasive ventilation or high-flow nasal oxygen. NivolisMonitor measures breathing parameters like pressure, flow, and oxygen levels, while Nivolis…

This study looked at whether a weak immune response to bacteria in COPD patients leads to more lung infections and flare-ups. Researchers collected sputum, blood, and nasal swabs from 23 hospitalized COPD patients during a flare-up and again 8 to 16 weeks later. The goal was to m…

This study aimed to see if spraying water on the body could help older adults with COPD stay cool during heat waves. Researchers planned to measure body temperature and lung function in a climate chamber. However, only one person took part before the study was stopped, so no mean…

This study used a special type of MRI (called hyperpolarized xenon-129 MRI) to take detailed pictures of lung function in 27 people with COPD who were scheduled to receive endobronchial valve therapy as part of their normal care. The goal was to see how the lungs work before and …