Congestive heart failure

Researchers are testing a mobile app designed to help people with heart failure manage their condition after leaving the hospital. The app sends personalized messages about low-sodium food choices and alerts based on daily symptom reports. The trial enrolls 62 adults recently hos…

This study is a large registry that will follow 5,000 people with heart failure who have received a Barostim implant. The goal is to see how well the device works in everyday medical practice to improve symptoms and quality of life. Participants are already implanted and will be …

Researchers are testing whether starting ivabradine when heart failure patients leave an observation unit safely lowers heart rate and reduces the chance of returning to the hospital or emergency room. The trial enrolls adults with reduced ejection fraction heart failure who are …

This trial tests whether a single intravenous iron infusion can improve exercise capacity in people with heart failure and iron deficiency. Participants are randomly assigned to receive the infusion or no treatment, then undergo cardiopulmonary exercise testing to measure peak ox…

This trial tests whether intravenous (IV) iron or oral iron pills work better for adults with congestive heart failure who also have low iron levels. Participants are randomly assigned to receive either a one-time IV infusion of ferric carboxymaltose (with a possible repeat dose)…

This study compared a device called Aquadex, which filters excess fluid from the blood, to standard IV diuretics in 167 hospitalized heart failure patients with fluid overload. The goal was to see which method better prevented heart failure events like rehospitalization. However,…

This study looked at whether the drug riociguat could improve right heart size and function in people with two types of pulmonary hypertension (PAH and CTEPH). It planned to enroll 30 adults, but was terminated early, so results are limited. The goal was to use echocardiograms to…

This study tested whether a once-daily dose of Torsemide (a water pill) works as well as the standard twice-daily Furosemide in heart failure patients. The goal was to see how much sodium the body gets rid of and if body weight changes. The study was stopped early and included 20…

This pilot study compared a heart ablation procedure (pulmonary vein isolation) to standard medications for managing atrial fibrillation in people with heart failure with preserved ejection fraction. Only 13 participants were enrolled before the study was terminated early. The ma…

This study tested whether a wearable device and digital care plan from the American Heart Association could help people with systolic heart failure. Participants wore the device for 90 days while their care team monitored their data. The trial was terminated early and only enroll…

This study tested an investigational drug called LY3540378 in 332 adults with worsening chronic heart failure where the heart pumps normally but doesn't fill properly (HFpEF). The goal was to see if the drug could improve heart function and safety compared to a placebo. The trial…

This study tested a drug called levosimendan to see if it could help people with severe heart failure successfully come off a temporary heart-lung machine (ECLS). The trial planned to include 82 adults who were ready to try weaning off the machine. Half would get the drug and hal…

This study tested an experimental drug called XXB750 in 136 people with heart failure. The goal was to see if it could improve heart function and symptoms. The trial was terminated early, so the full results are not available.

This study tested the drug riociguat in people with early pulmonary vascular disease, a condition where blood vessels in the lungs narrow, making the heart work harder. The trial included 35 adults with connective tissue disease or an inherited form. Participants received either …

This study tested a single dose of an experimental antibody called REGN5381 in 89 people with chronic heart failure and reduced pumping ability. The goal was to check safety, how the drug moves in the body, and its effects on heart stress markers. The trial was terminated early, …

This small study tested a drug called PL-3994 in 15 people with a type of heart failure where the heart pumps normally but doesn't relax properly. The goal was to see if the drug improved heart function and if effects differed between men and women. The trial was terminated early…

This study tested a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in people with chronic heart failure. The goal was to see if it is safe and feasible, and whether it could improve symptoms like walking distance and heart stra…

This early-stage trial tested an experimental drug called AZD3427 in 10 people with heart failure and reduced kidney function. The goal was to see if the drug could improve blood flow to the kidneys, measured with a special PET scan. However, the study was terminated early, so we…

This early study tested a new drug called AZD5462 added to the standard medicine dapagliflozin in people with heart failure and moderate kidney disease. Only 8 participants were enrolled before the study was stopped. The goal was to see if the combination is safe and affects how …

This was a very early (Phase 1) study testing a drug called HS135 in obese patients who have both pulmonary hypertension and a type of heart failure called HFpEF. The trial was terminated after enrolling only 4 people, so we have no useful information on whether HS135 is safe or …

This study looked at whether breathing air with less oxygen (like at high altitude) during exercise training could help people with heart failure do more physical activity. Only 14 patients were enrolled before the study was stopped early. The main goal was to see if this method …

This study tested if a gentle nerve stimulation (like a mild electrical pulse on the neck) could improve blood vessel health and memory in people with heart failure. Only 7 people took part before the study was stopped early. The goal was to see if 4 weeks of stimulation could re…

This study tested a program called HEART Camp Connect, which uses a virtual coach to help adults with heart failure exercise 150 minutes per week. Only 11 people enrolled before the trial was stopped. Researchers wanted to see if the program improved exercise habits and heart-rel…

This study tested whether a special breathing exercise program could help people with systolic heart failure walk farther and feel better. The trial planned to enroll 65 adults with moderate heart failure, but it was terminated early. Participants would have been assigned to eith…

This study tested whether providing palliative care at home, through a team of doctors, nurses, social workers, and chaplains, could improve symptoms and quality of life for people with advanced cancer, heart failure, or COPD. The plan was to enroll over 1,100 patients, but the t…

This study looked at how applying positive or negative pressure around the body affects exercise in people with heart failure with preserved ejection fraction. 27 participants, including healthy volunteers and heart failure patients, were tested non-invasively and some invasively…

This study tests a wearable device called the ADI Cardio Pulmonary Monitoring (CPM) system, designed to track heart failure signs at home. The goal is to see if the device can be easily used by patients and whether its measurements—like breathing rate and chest fluid levels—match…

This study is testing a wearable monitoring device designed for people with chronic heart failure to use at home. The device collects physiological data daily for five months, and researchers will then compare that data with any heart failure events, like hospitalizations or wors…

This study looked at whether implantable defibrillators (ICDs) help people with heart failure and a lower risk of deadly heart rhythms live longer compared to not having an ICD. It involved over 3,000 adults with weak heart pumps. The goal was to see if the benefits of ICDs still…

This study aims to find out how common transthyretin amyloidosis cardiomyopathy (ATTR-CM) is in Russian patients with a certain type of heart failure. Researchers will review medical records and then invite some patients for extra heart tests to confirm or rule out ATTR-CM. The g…

This pilot study tested an e-health system that uses tele-monitoring, tele-notification, and tele-coaching to help manage adults with at least two chronic conditions like heart failure, COPD, or diabetes. The goal was to see how well the system could detect health problems early.…