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Breathing therapy tested for heart failure – trial stopped early

NCT ID NCT05223751

Symptom relief Sponsor: Lancaster General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a special breathing exercise program could help people with systolic heart failure walk farther and feel better. The trial planned to enroll 65 adults with moderate heart failure, but it was terminated early. Participants would have been assigned to either standard care or standard care plus daily breathing exercises using a smartphone app and coaching.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
breathing exercises (Meo Health breathing therapy)
What this could lead to
If it worked, this could offer a simple, drug-free way to help people with heart failure feel better and walk farther.
What could go wrong
The trial was terminated early, so we have limited data. It was also a small study, and results may not apply to everyone with heart failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Feb 2022

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 18 years or older 2. Signed informed consent 3. NYHA class II-III heart failure 4. EF ≤ 45% (echo within 1 year of enrollment) 5. At least 30 days of stable medical regimen (no new neurohormonal blockade or Sodium-glucose co-transporter 2 inhibitors (SGLT2i). Dose adjustments allowed) 6. Likely to be compliant with breath training as assessed by the provider 7. Availability of a "smart" phone and internet access 8. Established care at Lancaster General Health Penn Medicine Exclusion Criteria: 1. Cardiac resynchronization therapy (CRT) within 6 months 2. Severe Chronic obstructive pulmonary disease (COPD) 3. History of diaphragm paralysis 4. Unable or unwilling to complete respiratory training protocol 5. Decompensated or American College of Cardiology (ACC) Stage D Heart Failure (HF) 6. Prior or planned chest/abdominal or nasal/facial surgery within 6 months 7. Neuromuscular disease which impairs respiration 8. Diagnosed cognitive impairment (unable to participate in training) 9. Untreated obstructive severe sleep apnea (AHI \> 30) 10. Severe valvular heart disease 11. Uncontrolled atrial fibrillation (Ave Heart Rate (HR) \> 100 bpm) 12. Orthopedic or other limitations which impair the 6-minute walk test

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diastolic heart failure

Contacts and locations

Locations

  • Lancaster General Hospital

    Lancaster, Pennsylvania, 17604, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.