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Could thin air help failing hearts? small study cut short

NCT ID NCT03537079

Symptom relief Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether breathing air with less oxygen (like at high altitude) during exercise training could help people with heart failure do more physical activity. Only 14 patients were enrolled before the study was stopped early. The main goal was to see if this method could safely improve exercise capacity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low-oxygen air (normobaric hypoxia)
What this could lead to
If this approach worked, it could point toward a new way to improve exercise ability and quality of life for people with heart failure.
What could go wrong
This was a very small, early study that was terminated before completion, so we cannot draw reliable conclusions. The intervention also carries risks like headache or dizziness from low oxygen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Feb 2021

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patient available for exercise training * stable heart failure state I-II New York Heart Association (NYHA) with altered ejection fraction (EF ≤ 40 %) * signed informed consent Exclusion Criteria: * unstable ischemic cardiopathy * right ventricle dysfunction * uncontrolled arrythmias * rest elevated in pulmonary artery pressure (≥ 45 mmHg) * migraine * high altitude trip above 2500 m high during study period * impossibility to realise a maximal bicycle exercise test

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Conditions

The condition(s) this trial relates to.

heart failure Hypoxia systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure, systolic

Contacts and locations

Locations

  • University Hospital

    Grenoble, 38000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.