Complex regional pain syndrome type 1

This phase 3 trial tests whether the drug neridronate, given as four IV infusions over 10 days, can reduce pain and other symptoms of complex regional pain syndrome type 1 (CRPS-1). About 270 adults with CRPS in one limb will receive either the drug or a placebo. The main goal is…

This trial tests whether extracorporeal shock wave therapy (ESWT), which delivers sound waves to painful areas, can ease symptoms of complex regional pain syndrome type I (CRPS-I) that sometimes follows a wrist fracture. Sixty adults with CRPS-I will receive standard rehabilitati…

This study is testing a new way to use an already-approved spinal cord stimulator to treat chronic, hard-to-manage back and leg pain. The device sends mild electrical pulses to the spine, and the new setting (called TVP-SCS) varies the timing of those pulses. Researchers will enr…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with severe Complex Regional Pain Syndrome (CRPS). Researchers will measure pain levels, wrist movement, and daily function in 60 adults with CRPS. The goal is to s…

This study tests whether a device that combines hot and cold therapy with gentle compression can reduce pain, swelling, and improve hand function in people with Complex Regional Pain Syndrome (CRPS) after a hand or wrist injury. Half of the participants will use this combined the…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or le…

This study tests whether task-based mirror therapy can reduce pain, swelling, and improve arm function in stroke survivors who develop shoulder-hand syndrome. Thirty-four participants aged 45-75 will be split into two groups: one doing mirror therapy plus standard exercises, the …

This study tests whether using a closed-loop spinal cord stimulator early in complex regional pain syndrome (CRPS) works better than waiting until the chronic phase. The device automatically adjusts its settings based on the body's signals. Researchers will enroll 32 adults with …

This study tests whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can reduce pain and improve arm function in stroke patients who develop complex regional pain syndrome. About 32 adults will receive the injection plus standard physical therap…