Combat disorder

This study explores whether shared decision-making—letting active-duty military personnel choose their PTSD treatment—improves engagement, retention, and outcomes. Participants are matched to one of three evidence-based therapies: Prolonged Exposure, Cognitive Processing Therapy,…

This study tests whether a single 45-minute psychiatric interview, given soon after ICU discharge for sepsis, can lower the risk of developing post-traumatic stress disorder (PTSD). Many ICU survivors face long-term mental health issues, but most hospitals lack early screening an…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests a new iPhone app called Senseye DT that uses artificial intelligence to diagnose Post-Traumatic Stress Disorder (PTSD) in adults. Participants will use the app while it records video of their face, and the AI looks for signs of PTSD. The goal is to see if the app…

People who need emergency surgery after a traumatic event like a car crash or fall face a higher risk of developing post-traumatic stress disorder. This trial tests whether giving the sedative dexmedetomidine during surgery, with or without adding a non-invasive ear stimulation c…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This study tests whether combining virtual reality therapy with a mild brain stimulation technique can help veterans and civilians in Ukraine cope with PTSD. Participants attend 10 therapy sessions using VR goggles to safely face traumatic memories, with some also receiving a gen…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This early-stage pilot study is testing whether psilocybin, a psychedelic compound, can be safely combined with trauma-focused psychotherapy for people with post-traumatic stress disorder (PTSD). Thirteen participants will receive two doses of psilocybin in a controlled setting, …

This study tests a new, quick brain stimulation treatment for PTSD. Fifteen adults with PTSD will get a brain scan to map their fear and control centers. Then, over 5 days, they receive many short magnetic pulses to strengthen brain connections and reduce symptoms. The study chec…

This study tests a program called Mental Gym® that uses a smartwatch and phone app to help combat veterans with PTSD. About 80 veterans will either start the program right away or wait a few months. The goal is to see if daily biofeedback exercises and group support can reduce PT…

This study tests a short, virtual therapy for pregnant women and new mothers with PTSD. About 90 participants will either receive the therapy or standard care. The goal is to see if the therapy is practical and well-liked, and to measure its effect on PTSD and depression symptoms…

This pilot study is testing whether transcranial magnetic stimulation (TMS) can help ease PTSD symptoms in veterans. Twenty veterans with moderate to severe PTSD will receive ten sessions of low-frequency TMS over 2–4 weeks. Researchers will also use brain scans and blood tests t…

This study tests whether a special computer-based brain training program can help adults with PTSD improve memory, attention, and daily functioning. Participants will be randomly assigned to either the brain training program or regular computer games, both with group discussions,…

This study tests a program called NurseNET, where nurses are trained to provide a short-term trauma therapy for PTSD. The goal is to make treatment easier to access for people who see their primary care nurse. Researchers will enroll 100 adults with PTSD symptoms and measure if s…

This study tests a handheld device called gammaCore that gently stimulates the vagus nerve in the neck, aiming to reduce PTSD symptoms. About 40 adults with PTSD will use the device at home for 12 weeks. Researchers will track symptom changes and safety to see if this approach co…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a program that improves how ICU staff care for patients can lower discomfort and reduce the risk of PTSD after leaving the hospital. About 1,242 adults who have been in the ICU for at least three days will take part. The program includes better communicat…

This study tests a new therapy called AMBET (Acceptance- and Mindfulness-Based Exposure Therapy) for treating PTSD in people who survived a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or a standard talk therapy (PCT) for 12 weeks. Researchers will tr…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce symptoms of post-traumatic stress disorder (PTSD). About 72 adults with PTSD will receive 60 treatments over 12 weeks, and researchers will track their symptoms for up t…

This pilot study tests a new way to deliver trauma-focused therapy to teens with PTSD. It combines therapist-led video sessions with a mobile app for self-paced exercises. Researchers want to see if this blended approach is feasible and acceptable compared to standard therapy. Ab…

This study tests whether listening to 15 minutes of frequency-filtered classical music before each cognitive processing therapy session can improve PTSD symptom relief. 100 adults with PTSD or subthreshold PTSD will be randomly assigned to hear either filtered or unfiltered music…

This study tests a new therapy called the Reconsolidation of Traumatic Memories (RTM) Protocol for people with PTSD in Ukraine. The goal is to reduce distressing symptoms like flashbacks and anxiety without requiring patients to relive their trauma in detail. The study will invol…

This study looks at whether art therapy can help active-duty military and recent veterans who have PTSD symptoms. Forty participants will attend 11 sessions over 6-8 months, including art therapy with a certified therapist and two MRI brain scans. The goal is to see if art therap…

This study tests whether 5 group sessions teaching mind-body skills can reduce PTSD symptoms and emotional problems in 120 adolescents aged 11-17 in Gaza who have experienced war-related trauma. Participants are randomly assigned to either the mind-body group or a control group, …

This study tests a quick, 5-day group therapy program for active-duty military and veterans who struggle with PTSD, insomnia, and nightmares. 160 participants will receive either cognitive-behavioral therapy or sleep education, both combined with a proven PTSD writing therapy. Th…

This study tests a software program designed to reduce symptoms of post-traumatic stress disorder (PTSD). About 52 adults with PTSD will use the software or a placebo version. Researchers will measure changes in PTSD severity using a standard scale over the study period.

This study is testing whether hyperbaric oxygen therapy (HBOT) can improve thinking, mood, and quality of life in veterans who have traumatic brain injury, PTSD, anxiety, or depression. Fifty-four veterans will receive multiple HBOT sessions in a pressurized chamber while breathi…

This pilot study tests whether a 5-day intensive therapy program can help teens aged 13–17 with PTSD. The program combines trauma-focused therapy, EMDR, physical activity, and parent support. Researchers want to see if it's practical and acceptable in Swedish child psychiatry, an…

This study tests whether brief educational videos delivered by text message can help young people aged 15-25 manage symptoms of post-traumatic stress disorder (PTSD). Participants are randomly assigned to receive the videos right away or after a 5-month wait. The study is fully o…

This study looks at teenagers aged 12 to 17 who live in child welfare care. Researchers want to understand emotional dysregulation, which is trouble managing emotions, in those who have experienced trauma. They aim to see if this emotional difficulty can help tell apart complex p…

This study compares different ways to train mental health providers in Written Exposure Therapy (WET), an effective treatment for PTSD. Some providers attend a live workshop via video, while others use a self-paced web-based program or an AI-powered training tool called TherapyTr…

This study looks at how a stellate ganglion block injection affects sleep in U.S. service members and veterans with PTSD who are already receiving talk therapy. About 40 participants will wear an EEG headband for three nights before and three nights after the injection to measure…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study is testing a new questionnaire called PTSD-iMPACT to see how well it measures the ways PTSD can interfere with daily life in children and adolescents. Researchers will include 1,200 participants from Switzerland and Germany, both those with and without PTSD symptoms. T…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at what to do when the first PTSD therapy doesn't work. Researchers will test different proven therapies on 400 adults who didn't respond to initial treatment. The goal is to find out which second treatment works best and create a tool to identify early who might…