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Brain zaps for war trauma? TMS shows promise in PTSD pilot

NCT ID NCT07336251

Symptom relief Sponsor: White River Junction Veterans Affairs Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether transcranial magnetic stimulation (TMS) can help ease PTSD symptoms in veterans. Twenty veterans with moderate to severe PTSD will receive ten sessions of low-frequency TMS over 2–4 weeks. Researchers will also use brain scans and blood tests to understand how TMS might work, focusing on brain activity and inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) – a device that uses magnetic pulses to stimulate brain areas
What this could lead to
If successful, this could point toward a non-drug treatment option for PTSD in veterans, potentially reducing symptoms like flashbacks and anxiety.
What could go wrong
This is a very small pilot study with only 20 participants, so results may not apply to all veterans. It is early-stage research focused on understanding mechanisms, not proving effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 19 and 70 * Eligible for VA healthcare * Moderate to severe PTSD as determined by a total score of at least 25 on the CAPS within 7 days of randomization. * Agree to have CAPS audio recorded. * Ability to obtain a Motor Threshold using the TMS device during screening. * If female with childbearing potential, use of acceptable method of birth control (i.e., use of contraceptives, abstinence). * Able to read, understand, and sign the informed consent document. Exclusion Criteria: * Pregnant or lactating woman. * MRI is contraindicated * Current use of clozapine (any dose) or bupropion (more than 300mg per day). * Cardiac pacemaker or implantable defibrillator. * Presence of any metal object in the head, including cochlear implants, but excluding dental work in the mouth. * Significant central nervous system disorder (stroke, brain mass, epilepsy). * Seizure in past one year. * Current psychosis or mania. * Significant suicidal ideation. * Unstable medical conditions. * Current alcohol or substance use disorder (except nicotine) that interferes with the patient's ability to participate. * CPT or PE for PTSD in the past 2 months. * Changes in Fluoxetine, Paroxetine, Sertraline, or Venlafaxine in the past 2 months. * Color blind * Currently participating in other research studies. * Aneurysm Clip * Ocular foreign body (e.g., metal shavings) * Any implanted device (pumps, infusion devices, etc.) * Shrapnel injuries or metal fragments

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Conditions

The condition(s) this trial relates to.

combat disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PTSD - post traumatic stress disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • White River Junction VA Hospital

    RECRUITING

    White River Junction, Vermont, 05001, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.