Clostridium infectious disease

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics…

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether taking capsules made from healthy donor stool (fecal microbiota transplantation, or FMT) can prevent another bout of C. diff infection in people who have had it come back at least twice. 76 adults will receive either active FMT capsules or placebo, and re…

This study provides a fecal transplant product made from healthy donor stool to treat people with recurrent Clostridium difficile infection or multidrug-resistant urinary tract infections. The product is delivered by courier or FedEx after a contract is signed. The goal is to res…

This study is testing whether transplanting stool from a healthy donor into the colon can prevent recurrent C. diff infections. The procedure, done via colonoscopy, aims to restore good bacteria that keep C. diff in check. Researchers are tracking 500 people to see if this stops …

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build …

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This study tests whether a specific diet can change gut bacteria and help prevent another C. difficile infection in adults who have had one. Twenty participants will receive prepared meals and health counseling, then follow a similar diet for 6 more weeks. Researchers will track …

This study tests whether giving a daily dose of oral vancomycin can prevent Clostridioides difficile (C. diff) infection in critically ill adults who are already on other antibiotics in the hospital. About 176 high-risk patients will receive either vancomycin or a placebo while t…

This study is building a large national registry to track the safety and effectiveness of fecal microbiota transplantation (FMT) in patients with Clostridium difficile infections. It will follow adult patients receiving FMT as part of their routine care, as well as stool donors, …

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study follows 60 adults who have had a C. diff infection return after standard antibiotic treatment. Researchers want to see how often the infection comes back within 8 weeks and whether measuring toxin levels in stool can predict that risk. Participants provide stool sample…

This study tracks how fecal microbiota transplantation (FMT) alters the gut microbiome in 20 adults with recurrent Clostridioides difficile infection. Researchers will analyze stool samples before and up to 90 days after FMT to see which bacteria take hold. The goal is to underst…

This study follows 100 hospitalized patients with Clostridioides difficile infection to track how quickly the bacteria clears from the gut during and after standard antibiotic treatment. Researchers will also analyze gut bacteria and immune responses in stool samples to identify …

This study watches 200 adults with C. diff infection to see how standard antibiotics and fecal microbiota transplantation (FMT) help people recover. Researchers will collect stool, blood, and urine samples over up to 5 years to understand why some treatments succeed and others fa…

This study is a national registry that will follow up to 4,000 people who receive a fecal microbiota transplant (FMT) for C. diff infection or other gut conditions. Researchers will track side effects, infections, and whether the disease comes back. The goal is to better understa…