Chronic ulcer of skin

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This phase 2 trial tests whether injecting antibiotics directly into the tissue around chronic wounds helps them heal better than standard care alone. About 60 adults with non-healing wounds on their legs, arms, or trunk will either receive the antibiotic injections plus usual wo…

This study tests a new hydrogel made with plasma-activated water on chronic wounds like diabetic foot ulcers and pressure sores. Fifty adults will either get the gel or standard wound care for 12 weeks. Researchers will check if the gel helps wounds close faster and lowers bacter…

This study tests a gel called ZKARE® for treating chronic ulcers that won't heal on their own. About 134 people with pressure sores, diabetic foot ulcers, or leg ulcers will either get the gel plus standard care, or standard care alone. The goal is to see if the gel helps wounds …

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study tests a wound dressing called Miro3D, made from pig liver tissue, to see if it helps heal hard-to-treat wounds like diabetic foot ulcers and pressure ulcers. Up to 20 adults will receive the dressing along with standard care for up to 12 weeks. Researchers will measure…

This study tests a new antibacterial absorbable dressing on 30 adults with chronic non-healing wounds. The dressing is designed to break down in the body and help wounds heal faster. Researchers will measure how much the wound shrinks after 3 weeks and how many wounds fully close…

This study tests whether adding live microalgae to a standard skin-regeneration scaffold helps deep wounds heal faster and with fewer infections. Twenty adults with full-thickness skin wounds will receive both the standard scaffold and the algae-enhanced version on different part…

This study explores whether a high-resolution ultrasound can better monitor healing in chronic wounds like diabetic foot ulcers. Ten participants will have their wounds scanned and biopsied to see if the ultrasound matches standard assessments. If it works, it could offer a painl…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This early-stage study tests a topical spray called ELU42 on 15 adults with diabetic foot ulcers (Wagner grade 1-2) that have lasted 4 to 52 weeks. The spray is applied three times a week for six weeks. The main goals are to check safety and measure how much the wound shrinks. Th…

This study compares two types of numbing medicine for upper limb surgery: a standard one and a longer-acting version. Researchers want to see how quickly the diaphragm (the main breathing muscle) recovers after the nerve block. 120 adults having arm or hand surgery will be split …

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study looks at genetic and epigenetic changes in chronic wounds that don't heal normally. Researchers will compare tissue from the wound with blood samples from 256 adults to find genetic signatures linked to healing. The goal is to understand why some wounds heal and others…