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Scientists hunt for genetic clues in stubborn wounds

NCT ID NCT03793062

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at genetic and epigenetic changes in chronic wounds that don't heal normally. Researchers will compare tissue from the wound with blood samples from 256 adults to find genetic signatures linked to healing. The goal is to understand why some wounds heal and others don't, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify genetic markers that predict wound healing, potentially guiding future treatments.
What could go wrong
This is an early observational study, not testing a treatment. It may not lead to direct clinical benefits or apply to all wound types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 256 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2018

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

256 clinically diagnosed chronic wound patients will be recruited for this study.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Willing to comply with protocol instructions, including all study visits and study activities. * Chronic wounds (\> than four weeks since onset) * Clinically diagnosed diabetic or non-diabetic ulcer. * For patients with multiple wounds, the largest wound will be used for the study. Exclusion Criteria: * Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent) * Pregnant females (self-declared) or lactating * Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications) * Prisoners

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Conditions

The condition(s) this trial relates to.

chronic ulcer of skin

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic wounds

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UPMC Wound Care Centers

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

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