Bone disorder
MONDO:0005381Diseases of bones.
Also known as: bone element disease, bone element disease or disorder, disease of bone element, disease or disorder of bone element, disorder of bone element, rare bone disease related to a common gene or pathway defect
6290 clinical trials for this condition and its sub-types, 53 tagged with Bone disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Bone disorder
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Bone inflammation disease 1 trial · 2,667 incl. sub-types
6 sub-types
- Arthritic joint disease 194 trials · 2,548 incl. sub-types Sub-types →
- Epicondylitis 86 trials
- Osteomyelitis 43 trials · 46 incl. sub-types Sub-types →
- Osgood-Schlatter disease 5 trials
- Mastoiditis 1 trial
- Caffey disease 0 trials
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Bone neoplasm 26 trials · 2,116 incl. sub-types
20 sub-types
- Bone cancer 79 trials · 1,921 incl. sub-types Sub-types →
- Skull neoplasm 0 trials · 161 incl. sub-types Sub-types →
- Bone benign neoplasm 1 trial · 70 incl. sub-types Sub-types →
- Notochordal tumor 0 trials · 34 incl. sub-types Sub-types →
- Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone 0 trials · 7 incl. sub-types Sub-types →
- Solitary bone cyst 6 trials
- Vascular bone neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Ollier disease 3 trials
- Hereditary multiple osteochondromas 3 trials Sub-types →
- Hyperparathyroidism 2 with jaw tumors 1 trial
- Neonatal severe primary hyperparathyroidism 1 trial
- Neoplasm of femur 0 trials · 1 incl. sub-types Sub-types →
- OSLAM syndrome 0 trials
- Aneurysmal bone cyst 0 trials
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Hyperparathyroidism 1 0 trials
- Hyperparathyroidism 3 0 trials
- Hyperparathyroidism 4 0 trials
- Juvenile hyaline fibromatosis 0 trials
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Skeletal dysplasia 1 trial · 660 incl. sub-types
119 sub-types
- Osteochondrodysplasia 12 trials · 380 incl. sub-types Sub-types →
- Lysosomal storage disease with skeletal involvement 0 trials · 63 incl. sub-types Sub-types →
- Chondrodysplasia punctata 0 trials · 39 incl. sub-types Sub-types →
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- Non-syndromic limb reduction defect 0 trials · 35 incl. sub-types Sub-types →
- FGFR3-related chondrodysplasia 0 trials · 33 incl. sub-types Sub-types →
- Abnormal mineralization disorder 0 trials · 22 incl. sub-types Sub-types →
- Syndromic craniosynostosis 1 trial · 22 incl. sub-types Sub-types →
- Osteopetrosis 6 trials · 14 incl. sub-types Sub-types →
- Amniotic band syndrome 8 trials · 9 incl. sub-types Sub-types →
- Primordial dwarfism and slender bone disorder 0 trials · 9 incl. sub-types Sub-types →
- Acromelic dysplasia 0 trials · 8 incl. sub-types Sub-types →
- Polydactyly-syndactyly-triphalangism 0 trials · 6 incl. sub-types Sub-types →
- McCune-Albright syndrome 5 trials
- SHOX-related short stature 5 trials
- Primary osteolysis 0 trials · 5 incl. sub-types Sub-types →
- Filamin-related bone disorder 0 trials · 4 incl. sub-types Sub-types →
- Ollier disease 3 trials
- Proteus syndrome 2 trials
- SLC26A2-related skeletal dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Acheiria 0 trials · 2 incl. sub-types Sub-types →
- Bent bone dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Congenital absence of both forearm and hand 1 trial · 2 incl. sub-types Sub-types →
- Metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome 2 trials
- Short rib dysplasia 0 trials · 2 incl. sub-types Sub-types →
- Spondylodysplastic dysplasia 0 trials · 2 incl. sub-types Sub-types →
- 2q37 microdeletion syndrome 1 trial
- COMP-related skeletal dysplasia 0 trials · 1 incl. sub-types Sub-types →
- Currarino triad 1 trial
- Sotos syndrome 1 trial
- Chondromalacia patellae 1 trial
- Coxopodopatellar syndrome 1 trial
- Craniofrontonasal syndrome 1 trial
- Bruck syndrome 0 trials Sub-types →
- Camurati-Engelmann disease 0 trials Sub-types →
- Catel-Manzke syndrome 0 trials
- Cole-Carpenter syndrome 0 trials Sub-types →
- Eiken syndrome 0 trials
- FAM111A-related skeletal dysplasia 0 trials Sub-types →
- Hartsfield-Bixler-Demyer syndrome 0 trials
- LRP5-related primary osteoporosis 0 trials
- Larsen-like osseous dysplasia-short stature syndrome 0 trials
- Larsen-like syndrome, B3GAT3 type 0 trials
- Lenz-Majewski hyperostotic dwarfism 0 trials
- Marshall-Smith syndrome 0 trials
- Richieri Costa-Pereira syndrome 0 trials
- Robinow syndrome 0 trials Sub-types →
- TRIP11-related skeletal dysplasia 0 trials Sub-types →
- TRPV4-related bone disorder 0 trials Sub-types →
- Tatton-Brown-Rahman overgrowth syndrome 0 trials
- Weaver syndrome 0 trials
- Yunis-Varon syndrome 0 trials
- Acrocoxomesomelic dysplasia 0 trials
- Adactyly of foot 0 trials Sub-types →
- Apodia 0 trials Sub-types →
- Autosomal dominant osteosclerosis, Worth type 0 trials
- Autosomal recessive cutis laxa type 2 0 trials Sub-types →
- Baby rattle pelvis dysplasia 0 trials
- Bird headed-dwarfism, Montreal type 0 trials
- Bone dysplasia Moore type 0 trials
- Bone dysplasia corpus callosum agenesis 0 trials
- Brachydactyly-elbow wrist dysplasia syndrome 0 trials
- Calvarial doughnut lesions with bone fragility and spondylometaphyseal dysplasia 0 trials
- Carpotarsal osteochondromatosis 0 trials
- Cerebrocostomandibular syndrome 0 trials
- Chondroectodermal dysplasia with night blindness 0 trials
- Cleidorhizomelic syndrome 0 trials
- Cognitive impairment - coarse facies - heart defects - obesity - pulmonary involvement - short stature - skeletal dysplasia syndrome 0 trials
- Colobomatous microphthalmia-rhizomelic dysplasia syndrome 0 trials
- Complex lethal osteochondrodysplasia 0 trials
- Congenital absence of both lower leg and foot 0 trials Sub-types →
- Congenital absence of thigh and lower leg with foot present 0 trials Sub-types →
- Congenital absence of upper arm and forearm with hand present 0 trials
- Craniometadiaphyseal dysplasia, wormian bone type 0 trials
- Craniotubular dysplasia, Ikegawa type 0 trials
- De la Chapelle dysplasia 0 trials
- Delayed membranous cranial ossification 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Dyschondrosteosis-nephritis syndrome 0 trials
- Dysplasia epiphysealis hemimelica 0 trials
- Dysplasia of head of femur, Meyer type 0 trials
- Dysspondyloenchondromatosis 0 trials
- Epimetaphyseal skeletal dysplasia 0 trials
- Familial osteodysplasia, Anderson type 0 trials
- Fibular aplasia-ectrodactyly syndrome 0 trials
- Genitopatellar syndrome 0 trials
- Genochondromatosis 0 trials Sub-types →
- Ghosal hematodiaphyseal dysplasia 0 trials
- Hyperostosis corticalis generalisata 0 trials
- Melorheostosis with osteopoikilosis 0 trials
- Mesomelic dwarfism-cleft palate-camptodactyly syndrome 0 trials
- Mesomelic dysplasia-digital anomalies-intellectual disability syndrome 0 trials
- Metaphyseal acroscyphodysplasia 0 trials
- Metaphyseal anadysplasia 0 trials Sub-types →
- Metaphyseal dysostosis-intellectual disability-conductive deafness syndrome 0 trials
- Metaphyseal dysplasia, Braun-Tinschert type 0 trials
- Microcephalic primordial dwarfism due to ZNF335 deficiency 0 trials
- Oculodentodigital dysplasia 0 trials Sub-types →
- Omodysplasia 0 trials Sub-types →
- Osteofibrous dysplasia 0 trials
- Osteoglophonic dysplasia 0 trials
- Pancreatic insufficiency-anemia-hyperostosis syndrome 0 trials
- Parietal foramina 0 trials Sub-types →
- Parietal foramina with cleidocranial dysplasia 0 trials
- Pelvic dysplasia-arthrogryposis of lower limbs syndrome 0 trials
- Proximal femoral focal deficiency 0 trials
- Pseudodiastrophic dysplasia 0 trials
- Rhizomelic dysplasia, Ain-Naz type 0 trials
- Rhizomelic dysplasia, Patterson-Lowry type 0 trials
- Rhizomelic syndrome, Urbach type 0 trials
- Short stature-advanced bone age-early-onset osteoarthritis syndrome 0 trials
- Skeletal dysplasia-epilepsy-short stature syndrome 0 trials
- Skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome 0 trials
- Split hand-foot malformation 1 with sensorineural hearing loss 0 trials
- Spondylometaphyseal dysplasia 0 trials Sub-types →
- Synpolydactyly 0 trials Sub-types →
- Tall stature-scoliosis-macrodactyly of the great toes syndrome 0 trials
- Thin ribs-tubular bones-dysmorphism syndrome 0 trials
- Tricho-dento-osseous syndrome 0 trials
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Bone development disease 2 trials · 527 incl. sub-types
9 sub-types
- Osteochondrodysplasia 12 trials · 380 incl. sub-types Sub-types →
- Dysostosis 0 trials · 85 incl. sub-types Sub-types →
- Developmental dysplasia of the hip 62 trials Sub-types →
- Spondylocarpotarsal synostosis syndrome 2 trials
- Microcephalic osteodysplastic dysplasia, Saul-Wilson type 1 trial
- Angioosteohypotrophic syndrome 0 trials
- Brachydactyly-elbow wrist dysplasia syndrome 0 trials
- Odontoid hypoplasia 0 trials
- Segmental odontomaxillary dysplasia 0 trials
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Disease of bone structure 1 trial · 456 incl. sub-types
5 sub-types
- Scoliosis 137 trials · 234 incl. sub-types Sub-types →
- Spinal stenosis 120 trials · 154 incl. sub-types Sub-types →
- Spondylolisthesis 77 trials Sub-types →
- Spondylosis 70 trials
- Spondylolysis 6 trials
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Bone remodeling disease 5 trials · 411 incl. sub-types
6 sub-types
- Bone resorption disease 23 trials · 319 incl. sub-types Sub-types →
- Rickets 10 trials · 41 incl. sub-types Sub-types →
- Hyperostosis 2 trials · 26 incl. sub-types Sub-types →
- Osteosclerosis 1 trial · 16 incl. sub-types Sub-types →
- Fibrous dysplasia 11 trials Sub-types →
- Osteomalacia 2 trials · 4 incl. sub-types Sub-types →
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Skull disorder 1 trial · 387 incl. sub-types
6 sub-types
- Paranasal sinus disorder 12 trials · 162 incl. sub-types Sub-types →
- Skull neoplasm 0 trials · 161 incl. sub-types Sub-types →
- Disorder of facial skeleton 4 trials · 132 incl. sub-types Sub-types →
- Cochlear disorder 6 trials
- Enlarged vestibular aqueduct syndrome 2 trials
- Petrositis 0 trials
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Metabolic bone disorder 9 trials · 316 incl. sub-types
4 sub-types
- Osteoporosis 277 trials · 295 incl. sub-types Sub-types →
- Chondrocalcinosis 5 trials · 7 incl. sub-types Sub-types →
- Osteomalacia 2 trials · 4 incl. sub-types Sub-types →
- Bone Paget disease 2 trials Sub-types →
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Osteonecrosis 59 trials · 224 incl. sub-types
7 sub-types
- Avascular necrosis 80 trials · 141 incl. sub-types Sub-types →
- Osteonecrosis of genetic origin 0 trials · 102 incl. sub-types Sub-types →
- Osteochondrosis 8 trials · 46 incl. sub-types Sub-types →
- Osteoradionecrosis 14 trials · 15 incl. sub-types Sub-types →
- Dieterich disease 1 trial
- Kummell disease 1 trial
- Idiopathic phalangeal acro-osteolysis 0 trials
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Mucopolysaccharidosis type 3 7 trials · 18 incl. sub-types
4 sub-types
- Mucopolysaccharidosis type 3A 7 trials
- Mucopolysaccharidosis type 3B 6 trials
- Mucopolysaccharidosis type 3C 2 trials
- Mucopolysaccharidosis type 3D 0 trials
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Mucopolysaccharidosis type 1 11 trials · 16 incl. sub-types
3 sub-types
- Hurler syndrome 6 trials
- Hurler-Scheie syndrome 2 trials
- Scheie syndrome 1 trial
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Periostitis 0 trials · 16 incl. sub-types
2 sub-types
- Alveolar periostitis 16 trials
- Orbital periostitis 0 trials
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GM1 gangliosidosis 12 trials
3 sub-types
- GM1 gangliosidosis type 1 3 trials
- GM1 gangliosidosis type 2 3 trials
- GM1 gangliosidosis type 3 0 trials
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Mucopolysaccharidosis type 9 1 trial
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ACAN-related short stature spectrum 0 trials · 1 incl. sub-types
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Baastrup syndrome 0 trials
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Sagliker syndrome 0 trials
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Ainhum 0 trials
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Cervical rib disease 0 trials
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Coxoauricular syndrome 0 trials
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Metachondromatosis 0 trials
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Mueller-weiss syndrome 0 trials
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Proteoglycan-related bone disorder 0 trials
Most studied deeper sub-types
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Could your own bone marrow cells save your hip from collapse?
Disease control Recruiting nowThis study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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New drug aims to boost growth in kids with noonan syndrome
Disease control Recruiting nowThis study tests vosoritide, a protein that stimulates bone growth, in 30 children with Noonan syndrome who are not growing well despite growth hormone treatment. The goal is to see if vosoritide can safely increase their growth rate over six months. Participants will receive one…
Phase 2 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New drug aims to boost height in kids with dwarfism
Disease control Recruiting nowThis study tests a new medicine called BMN 333 against an existing drug (vosoritide) to see if it can safely improve growth in children with achondroplasia, the most common form of dwarfism. About 160 children aged 2 to 17 will take part. The goal is to measure how much they grow…
Phase 2/3 • Sponsor: BioMarin Pharmaceutical • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Bone drug tested to shield young transplant survivors from fractures
Disease control Recruiting nowThis early study tests whether giving a bone-strengthening drug called zoledronate soon after a stem cell transplant can safely prevent bone loss and fractures in children. Researchers will enroll 20 children aged 5 to 18 who are at high risk for bone problems. The goal is to see…
Phase 1 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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New cartilage implant aims to outperform microfracture for ankle injuries
Disease control Recruiting nowThis Phase 3 trial tests whether a lab-grown cartilage implant (MACI) can better repair painful ankle cartilage defects than the standard microfracture procedure. About 309 adults aged 17-65 with ankle cartilage damage will be randomly assigned to receive either MACI or microfrac…
Phase 3 • Sponsor: Vericel Corporation • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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New pill could help kids with dwarfism grow better
Disease control Recruiting nowThis study tests an oral drug called infigratinib in infants and children under 3 years old with achondroplasia, the most common form of dwarfism. The goal is to see if it safely improves growth and body proportions. The trial has several phases to find the right dose and then co…
Phase 2 • Sponsor: QED Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Hip replacement vs. metal rods: which surgery is better for bone cancer?
Disease control Recruiting nowThis study looks at two types of hip surgery for people whose cancer has spread to the hip bone. One surgery removes the damaged bone and replaces it with an artificial joint. The other uses metal rods and plates to hold the bone together. The goal is to see which surgery leads t…
Sponsor: Michelle Ghert, MD • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New bone cement under study: could it improve healing after orthopedic surgery?
Disease control Recruiting nowThis study is testing a bone cement called Neocement® to see how well it fills bone defects caused by surgery or injury. Researchers will check if the bone heals properly and if there are any side effects. About 80 adults who need bone defect treatment will take part, and their r…
Sponsor: Bioceramed • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New bone cement under study for safer orthopedic recovery
Disease control Recruiting nowThis study is testing a bone cement called Neocement Inject P in 80 adults who need bone defect repair during orthopedic surgery. The goal is to see how well it helps bones heal and whether it causes any side effects in real-world use. Participants will be followed with X-rays or…
Sponsor: Bioceramed • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Gum disease repair: which bone graft works best?
Disease control Recruiting nowThis study tests two different bone graft materials—one from cow bone and one synthetic—combined with a special enamel protein to repair deep gum and bone defects caused by periodontitis. Forty adults with at least one deep gum pocket (6 mm or more) and a bone defect will receive…
Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for rare bone disease: first human trial of KK8123 begins
Disease control Recruiting nowThis study tests a new drug called KK8123 for adults with X-linked hypophosphatemia (XLH), a rare genetic condition that causes low phosphate levels and bone problems. The trial has two parts: first, finding the right dose, then checking safety and how well it works over time. Ab…
Phase 1/2 • Sponsor: Kyowa Kirin Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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New MRI could replace CT scans for spine imaging
Diagnosis Recruiting nowThis study tests a new MRI technique called BoneMRI that creates CT-like images of the spine without using radiation. Researchers will compare BoneMRI images to standard CT scans in 450 people who need both scans. If accurate, BoneMRI could allow doctors to diagnose and plan spin…
Sponsor: MRIguidance B.V. • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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NIH launches major study to unlock secrets of rare bone diseases
Knowledge-focused Recruiting nowThis study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Can discarded bone reveal the secrets to stronger bones?
Knowledge-focused Recruiting nowThis study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …
Sponsor: Relation Therapeutics • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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Smartwatches could predict complications in bone cancer patients
Knowledge-focused Recruiting nowThis study is testing whether a smartwatch can track changes in walking and daily activities in people with bone cancer (osteosarcoma or metastatic bone disease). The goal is to see if the watch can help doctors spot problems early and personalize care. About 60 participants will…
Sponsor: Case Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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New study tracks growth in kids with rare bone disorder
Knowledge-focused Recruiting nowThis study watches children aged 2.5 to 17 with hypochondroplasia, a condition causing short stature, to track their growth and health over time. No treatments or drugs are given. The goal is to learn more about how the condition affects growth, body proportions, thinking skills,…
Sponsor: QED Therapeutics, a BridgeBio company • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Bone disease biobank launches to uncover hidden clues
Knowledge-focused Recruiting nowThis study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Major study aims to predict pain relief in bone cancer patients
Knowledge-focused Recruiting nowThis study will follow 2500 cancer patients with bone metastases to better understand why some respond to radiation therapy and others do not. Researchers will collect data to build tools that predict pain relief and survival, and to create a platform for testing new treatments. …
Sponsor: UMC Utrecht • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Brittle bones, fragile hearts? new study investigates cardiac risks in OI
Knowledge-focused Recruiting nowThis study is observing 40 people with osteogenesis imperfecta (brittle bone disease) to see how often heart problems occur. Researchers will use standard heart tests like echocardiograms to check for issues. The goal is to create better screening guidelines to catch heart proble…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Can estrogen patches strengthen bones in women with CF?
Knowledge-focused Recruiting nowThis study looks at how estrogen and other hormones affect bone development in teenage and young adult women with cystic fibrosis (CF). It has two parts: an observational study that tracks bone health in women using different types of birth control, and a small feasibility study …
Phase 4 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC