Autoimmune disease

MONDO:0007179

A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

Also known as: autoimmune disease, autoimmune disease or disorder, autoimmune disorder, disease, autoimmune, autoimmune hypersensitivity disease, hypersensitivity reaction type II disease

4033 clinical trials for this condition and its sub-types, 313 tagged with Autoimmune disease itself.

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Where it sits in the disease tree

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Part of

↑ Immune system disorder (12959)

Sub-types of Autoimmune disease

Autoimmune disorder of the nervous system 47 trials · 1,060 incl. sub-types
4 sub-types
- Autoimmune disorder of central nervous system 2 trials · 874 incl. sub-types Sub-types →
- Autoimmune disorder of peripheral nervous system 0 trials · 194 incl. sub-types Sub-types →
- Pediatric acute-onset neuropsychiatric syndrome 8 trials · 10 incl. sub-types Sub-types →
- Autoimmune retinopathy 0 trials
Autoimmune disorder of gastrointestinal tract 0 trials · 936 incl. sub-types
7 sub-types
- Type 1 diabetes mellitus 815 trials · 816 incl. sub-types Sub-types →
- Celiac disease 79 trials Sub-types →
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Autoimmune enteropathy 2 trials · 11 incl. sub-types Sub-types →
- Autoimmune gastritis 3 trials
- Autoimmune pancreatitis 3 trials Sub-types →
- IgG4-related sclerosing cholangitis 0 trials
Autoimmune disorder of endocrine system 1 trial · 925 incl. sub-types
13 sub-types
- Type 1 diabetes mellitus 815 trials · 816 incl. sub-types Sub-types →
- Autoimmune thyroid disease 8 trials · 62 incl. sub-types Sub-types →
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Autoimmune polyendocrinopathy 3 trials · 11 incl. sub-types Sub-types →
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome 10 trials
- Autoimmune hypoparathyroidism 0 trials · 8 incl. sub-types Sub-types →
- Autoimmune pancreatitis 3 trials Sub-types →
- Autoimmune primary ovarian failure 1 trial
- IgG4-related sclerosing cholangitis 0 trials
- Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome 0 trials
- Autoimmune oophoritis 0 trials
- Insulin autoimmune syndrome 0 trials
- Primary hypophysitis 0 trials Sub-types →
CNS demyelinating autoimmune disease 5 trials · 853 incl. sub-types
1 sub-type
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
Autoimmune disorder of musculoskeletal system 0 trials · 795 incl. sub-types
3 sub-types
- Rheumatoid arthritis 576 trials · 795 incl. sub-types Sub-types →
- Autoimmune cardiomyopathy 0 trials Sub-types →
- Neonatal dermatomyositis 0 trials
Lupus erythematosus 39 trials · 548 incl. sub-types
3 sub-types
- Systemic lupus erythematosus 516 trials · 522 incl. sub-types Sub-types →
- Cutaneous lupus erythematosus 38 trials · 46 incl. sub-types Sub-types →
- Drug-induced lupus erythematosus 1 trial
Scleroderma 47 trials · 305 incl. sub-types
3 sub-types
- Systemic sclerosis 261 trials · 295 incl. sub-types Sub-types →
- Localized scleroderma 14 trials · 15 incl. sub-types Sub-types →
- Neonatal scleroderma 0 trials
Autoimmune disorder of exocrine system 0 trials · 196 incl. sub-types
3 sub-types
- Sjogren syndrome 166 trials
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Benign lymphoepithelial lesion of salivary gland 0 trials
Autoimmune disorder of blood 0 trials · 152 incl. sub-types
2 sub-types
- Primary thrombocytopenia 27 trials · 110 incl. sub-types Sub-types →
- Autoimmune hemolytic anemia 49 trials · 72 incl. sub-types Sub-types →
Autoimmune thrombocytopenia 8 trials · 113 incl. sub-types
2 sub-types
- Autoimmune thrombocytopenic purpura 95 trials
- Evans syndrome 19 trials
Vitiligo 100 trials
3 sub-types
- Generalized vitiligo 16 trials
- Alopecia universalis onychodystrophy vitiligo 0 trials
- Trichrome vitiligo 0 trials
Antiphospholipid syndrome 58 trials · 59 incl. sub-types
4 sub-types
- Primary antiphospholipid syndrome 4 trials
- Catastrophic antiphospholipid syndrome 1 trial
- Familial antiphospholipid syndrome 0 trials
- Secondary antiphospholipid syndrome 0 trials Sub-types →
Autoimmune bullous skin disease 7 trials · 55 incl. sub-types
11 sub-types
- Pemphigus 20 trials · 27 incl. sub-types Sub-types →
- Bullous pemphigoid 18 trials
- Mucous membrane pemphigoid 5 trials · 9 incl. sub-types Sub-types →
- Acquired epidermolysis bullosa 3 trials
- Dermatitis herpetiformis 1 trial Sub-types →
- Pemphigoid 1 trial
- IgA pemphigus 0 trials
- Anti-p200 pemphigoid 0 trials
- Linear IgA Dermatosis 0 trials
- Paraneoplastic pemphigus 0 trials
- Subcorneal pustular dermatosis 0 trials
Immunoglobulin G4-related sclerosing disease 30 trials · 34 incl. sub-types
14 sub-types
- Autoimmune pancreatitis 3 trials Sub-types →
- IgG4-related kidney disease 1 trial
- IgG4-related retroperitoneal fibrosis 1 trial Sub-types →
- IgG4-related aortitis 0 trials
- IgG4-related mediastinitis 0 trials
- IgG4-related mesenteritis 0 trials
- IgG4-related ophthalmic disorder 0 trials Sub-types →
- IgG4-related pachymeningitis 0 trials
- IgG4-related sclerosing cholangitis 0 trials
- IgG4-related submandibular gland disease 0 trials
- IgG4-related thyroid disease 0 trials
- Cutaneous pseudolymphoma 0 trials
- Eosinophilic angiocentric fibrosis 0 trials
- Primary cutaneous plasmacytosis 0 trials
Rheumatic fever 16 trials
Overlapping connective tissue disease 2 trials · 15 incl. sub-types
2 sub-types
- Mixed connective tissue disease 15 trials
- MASS syndrome 0 trials
Autoimmune lymphoproliferative syndrome 11 trials · 12 incl. sub-types
9 sub-types
- Autoimmune lymphoproliferative syndrome type 4 3 trials
- FAS-related autoimmune lymphoproliferative syndrome 2 trials
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency 1 trial
- Castleman-Kojima disease 0 trials
- Autoimmune lymphoproliferative syndrome type 1 0 trials
- Autoimmune lymphoproliferative syndrome type 2A 0 trials
- Autoimmune lymphoproliferative syndrome type 2B 0 trials
- Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD 0 trials
- Type 3 autoimmune lymphoproliferative syndrome 0 trials
Undifferentiated connective tissue syndrome 7 trials
Autoimmune pulmonary alveolar proteinosis 6 trials
Type III hypersensitivity disease 3 trials · 6 incl. sub-types
2 sub-types
- Serum sickness 3 trials
- Arthus reaction 0 trials
Anti-glomerular basement membrane disease 5 trials
Autoimmune disease of ear, nose and throat 0 trials · 4 incl. sub-types
7 sub-types
- Autoimmune inner ear disease 2 trials
- Autoimmune uveitis 2 trials
- Cogan syndrome 0 trials
- IgG4-related dacryoadenitis and sialadenitis 0 trials
- IgG4-related submandibular gland disease 0 trials
- Autoimmune retinopathy 0 trials
- Eosinophilic angiocentric fibrosis 0 trials
Cryoglobulinemia 3 trials
1 sub-type
- Cryofibrinogenemia 0 trials Sub-types →
Autoimmune disorder of cardiovascular system 0 trials · 3 incl. sub-types
6 sub-types
- Chilblain lupus 1 trial · 3 incl. sub-types Sub-types →
- Libman-Sacks endocarditis 0 trials
- Autoimmune atherosclerosis 0 trials
- Autoimmune cardiomyopathy 0 trials Sub-types →
- Autoimmune vasculitis 0 trials Sub-types →
- Rheumatic pulmonary valve disease 0 trials
Susac syndrome 2 trials
Autoimmune disease, multisystem, infantile-onset 0 trials · 2 incl. sub-types
4 sub-types
- STAT3-related early-onset multisystem autoimmune disease 2 trials
- Autoimmune disease, multisystem, infantile-onset, 2 0 trials
- Autoimmune disease, multisystem, infantile-onset, 3 0 trials
- Autoimmune disease, multisystem, infantile-onset, 5 0 trials
Anti-neutrophil antibody associated vasculitis 1 trial
Phacolytic glaucoma 1 trial
Secondary neonatal autoimmune disease 0 trials · 1 incl. sub-types
6 sub-types
- Neonatal lupus erythematosus 1 trial
- Neonatal antiphospholipid syndrome 0 trials
- Neonatal autoimmune hemolytic anemia 0 trials
- Neonatal dermatomyositis 0 trials
- Neonatal scleroderma 0 trials
- Transient neonatal myasthenia gravis 0 trials
Jaccoud syndrome 0 trials
Kimura disease 0 trials
Reynolds syndrome 0 trials
Autoerythrocyte sensitization syndrome 0 trials
Autoimmune disease with susceptibility to mycobacterium tuberculosis 0 trials
Autoimmune glomerulonephritis 0 trials
Autoimmune pulmonary disease due to PD-1 deficiency 0 trials
Autoimmune urticaria 0 trials
Euthyroid Graves orbitopathy 0 trials
Multisystem autoimmune disease due to IKAROS gain of function 0 trials
Non-specific autoimmune brainstem encephalitis with characteristic antibodies 0 trials
Non-specific autoimmune brainstem encephalitis without characteristic antibodies 0 trials
Non-specific autoimmune cerebellar ataxia with characteristic antibodies 0 trials
Non-specific autoimmune cerebellar ataxia without characteristic antibodies 0 trials
Non-specific autoimmune supratentorial encephalitis with characteristic antibodies 0 trials
Non-specific autoimmune supratentorial encephalitis without characteristic antibodies 0 trials
Tempi syndrome 0 trials
Type II hypersensitivity reaction disease 0 trials

Most studied deeper sub-types

Relapsing-remitting multiple sclerosis (262) Psoriatic arthritis (188) Myasthenia gravis (158) Ankylosing spondylitis (109) Diffuse scleroderma (82) Chronic progressive multiple sclerosis (81) Secondary progressive multiple sclerosis (65) Primary progressive multiple sclerosis (57) Graves disease (53) Autoimmune encephalitis (32) Diffuse cutaneous systemic sclerosis (30) Autoimmune hemolytic anemia, warm type (29) Pulmonary systemic sclerosis (27) Guillain-Barre syndrome (23) Discoid lupus erythematosus (17) Pediatric systemic lupus erythematosus (16) Hashimoto thyroiditis (15) Polyneuropathy, inflammatory demyelinating, chronic (15) Psoriasis-related juvenile idiopathic arthritis (15) Cold agglutinin disease (14)

Including sub-types (4033) Tagged with Autoimmune disease (313)

Trials to join now! 153 Not yet recruiting 41 Not yet finished but already full! 45 Completed 57 Terminated 17

Autoimmune disease

Where it sits in the disease tree

Most studied deeper sub-types

Can a single infusion of reprogrammed immune cells quiet lupus kidney disease?

Can a single CAR-T infusion reset the immune system and stop lupus kidney damage?

Can a One-Time cell therapy reset the immune system in autoimmune disease?

Could stem cells plus supercharged immune cells tame autoimmune disease?

Engineered immune cells take aim at autoimmune diseases

Fetal stem cells aim to tame immune chaos

Can a new pill quiet the inflammation of rheumatoid arthritis?

Could a single injection reprogram immune cells to tame lupus and scleroderma?

Can a bispecific antibody tame two autoimmune blood disorders?

Can an online brain workout sharpen thinking in multiple sclerosis?

Gene therapy aims to tame rare immune disorder

Engineered immune cells take aim at childhood autoimmune diseases

Engineered immune cells take aim at Hard-to-Treat lupus

Experimental drug aims to tame stubborn autoimmune diseases

New drug HBM7020 tested in humans for first time against autoimmune diseases

New hope for ulcerative colitis patients who failed biologics?

Can a shingles vaccine and diabetes drug save insulin cells?

Experimental CAR-T injection aims to tame autoimmune diseases

New drug STR-P005 aims to tame stubborn autoimmune diseases

New gene therapy trial targets tough autoimmune conditions

MRNA technology takes on autoimmune diseases in early trial

New drug STR-P004 aims to tame immune attacks on kidneys

MRNA technology takes on autoimmune diseases in new trial

New mRNA shot aims to calm stubborn autoimmune diseases

Immune system reset: CAR T-Cells take on autoimmune diseases

New hope for rare nerve disease: can a biologic drug cut steroid use?

A finger prick instead of a needle: could At-Home blood tests match hospital accuracy?

New study aims to catch type 1 diabetes early in kids

Yearly TB check may shield vulnerable patients from a hidden threat

Could one antibiotic dose before tooth pulling prevent infections in Immune-Weakened patients?

New hope for stiff person syndrome: drug trial aims to ease muscle stiffness and improve walking

Finger injections aim to loosen stiff hands in scleroderma

Could weekly yoga ease fatigue and pain in autoimmune disease?

Could menopause trigger autoimmune conditions? a new study investigates

Scientists target GLUT1 to tame immune attacks in type 1 diabetes

Scientists build lab models of scleroderma from Patients' blood cells

15-Year safety check for experimental cell therapy

New study tracks 300 people at risk for type 1 diabetes over 10 years

Massive study to uncover hidden link between blood mutations and immune disorders

Can hospitals boost vaccine access for the most vulnerable?

Lupus patients wanted: new italian registry hopes to unlock better care