Arterial occlusion

This study tests a device called the Artix Thrombectomy System to remove blood clots from leg arteries in people with sudden blockages. About 250 adults with symptoms lasting up to 14 days will be enrolled. The goal is to see if the device can safely restore blood flow and preven…

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This study is testing a covered stent called BeFlow to treat narrowed or blocked iliac arteries in the pelvis. Researchers will monitor 100 patients to see how well the stent restores blood flow and how safe it is. The goal is to improve walking ability and reduce pain caused by …

This study is testing whether giving the blood thinner heparin before inserting a tube into the wrist artery can prevent a common complication: blockage of that artery. About 550 people undergoing a heart procedure through the wrist will be randomly assigned to receive heparin ei…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a major stroke and undergone a procedure to remove a blood clot from a large brain artery. Even when the clot is successfully removed, many patients still have significant disability. …

This study tests whether adding the antibiotic minocycline to standard stroke treatment can improve recovery in people who had a severe stroke in the back of the brain. After a clot is removed, brain inflammation can limit healing. Minocycline may reduce that inflammation. The tr…

This study tests whether a special cold plasma treatment, given daily for 10 days after a leg artery procedure, can help heal diabetic foot ulcers faster. About 40 adults aged 18–80 with diabetes and blocked leg arteries will take part. Half will get real plasma, half a fake trea…

This study compares two treatments for people with completely blocked heart arteries (chronic total occlusions). One group gets a drug-coated balloon, with or without a stent; the other gets standard stents. The goal is to see if the balloon approach keeps arteries open just as w…

This study tests whether adding cold atmospheric plasma to standard artery-opening treatment helps heal diabetic foot ulcers faster. About 86 adults with diabetes and blocked leg arteries will receive either real or fake plasma sessions over two weeks. The goal is to see if the p…

This study collects information from 150 adults with antiphospholipid syndrome who had an artery clot in the past year. Participants are already on one of four blood-thinning treatments. Researchers will track who has another clot or a major bleed over two years to see which trea…

This study tests whether giving the blood thinner heparin only when needed, instead of routinely, can prevent radial artery occlusion after a heart catheterization procedure. Researchers will enroll 500 patients and compare rates of artery patency, bleeding, and nursing time. The…

This study tests a minimally invasive procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with chronic shoulder pain from rotator cuff tendinopathy that hasn't improved with standard treatments. About 41 adults with moderate to sev…

This study compares two methods of pain control for people having open abdominal surgery. One group gets a single injection of a long-lasting numbing medicine into the belly muscles during surgery. The other group gets a standard numbing medicine through small tubes placed in the…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This study looks at how often lung cancer patients on immune checkpoint inhibitors develop blood clots (in veins or arteries) and what factors increase that risk. Researchers will follow 2,400 adults with lung cancer who are starting immunotherapy, comparing those who get clots w…

This study is for adults with a blocked radial artery who need a heart procedure like angiography or angioplasty. Doctors will use the ulnar artery in the same wrist instead. The goal is to see if this approach is safe and how it affects hand strength, feeling, and daily use. Res…