Adrenocortical insufficiency
MONDO:0000004An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).
Also known as: adrenal cortical hypofunction, adrenal cortical insufficiency, adrenal gland insufficiency, adrenal insufficiency, adrenocortical insufficiency, hypocortisolemia, hypocortisolism, hypoadrenalism
78 clinical trials for this condition and its sub-types, 33 tagged with Adrenocortical insufficiency itself.
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Sub-types of Adrenocortical insufficiency
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Primary adrenal insufficiency 5 trials · 48 incl. sub-types
2 sub-types
- Chronic primary adrenal insufficiency 6 trials · 47 incl. sub-types Sub-types →
- Acute adrenal insufficiency 0 trials Sub-types →
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Secondary adrenal insufficiency 3 trials
Most studied deeper sub-types
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Could a spoonful of yoghurt replace awkward tongue dosing for a lifesaving steroid?
Disease control CompletedResearchers are testing whether hydrocortisone granules (Infacort) mixed with yoghurt or soft food get into the bloodstream as well as dry granules placed on the back of the tongue. The study enrolls 19 healthy adult men whose natural cortisol is temporarily suppressed with dexam…
Phase 1 • Sponsor: Neurocrine UK Limited • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Granule vs tablet: can a new hydrocortisone form match the standard?
Disease control CompletedResearchers are testing whether a granule form of hydrocortisone called Infacort is absorbed into the body as well as standard hydrocortisone tablets (Cortef). The study enrolls healthy adults aged 18 to 55 and gives each participant both forms in a random order, once while fasti…
Phase 1 • Sponsor: Neurocrine UK Limited • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Can a modified hydrocortisone mimic the Body's natural cortisol rhythm?
Disease control CompletedResearchers are testing Chronocort, a modified-release form of hydrocortisone, against standard immediate-release hydrocortisone in 30 healthy male volunteers. The study measures how the drug moves through the body, including how fast it reaches peak levels and how long it stays …
Phase 1 • Sponsor: Neurocrine UK Limited • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Can a Timed-Release hydrocortisone pill match the Body's overnight hormone rhythm?
Disease control CompletedResearchers are testing several modified, timed-release versions of hydrocortisone, a hormone drug, in healthy male volunteers. The study has two parts: one compares how six different formulations move through the body after a single nighttime dose, and the other checks whether t…
Phase 1 • Sponsor: Neurocrine UK Limited • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Can a Modified-Release hydrocortisone mimic the Body's natural rhythm?
Disease control CompletedResearchers are testing how the body absorbs Chronocort, a modified-release hydrocortisone, compared with Cortef, a standard immediate-release hydrocortisone tablet. The study enrolls healthy adult men whose natural cortisol production is temporarily suppressed with dexamethasone…
Phase 1 • Sponsor: Neurocrine UK Limited • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Could cheap steroids help hearts in shock?
Disease control CompletedThis study tested whether giving low doses of two steroids (hydrocortisone and fludrocortisone) helps adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. 380 participants received either the steroids or a placebo. The main goal was…
Phase 3 • Sponsor: CMC Ambroise Paré • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Study aims to uncover hidden hormone failure in ICU patients
Knowledge-focused CompletedThis study looks at how the adrenal glands work in people who are critically ill, such as those with sepsis. Adrenal insufficiency may affect up to 77% of ICU patients, but current tests are not reliable. Researchers will measure hormone levels in 225 participants, including heal…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Scientists probe link between stress hormone and 'Bliss Molecule' in rare disease
Knowledge-focused CompletedThis study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Hidden danger: low blood sugar in kids with adrenal gland disorder
Knowledge-focused CompletedThis study looked at how often children with a rare adrenal gland problem (congenital adrenal insufficiency) experience dangerously low blood sugar. Even with standard treatment, these children may have low blood sugar without obvious symptoms. Researchers monitored 9 children ag…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Diabetes drug semaglutide put to the test: can it reveal secrets of the adrenal gland?
Knowledge-focused CompletedThis completed study gave 22 healthy men a single dose of semaglutide (Rybelsus) or a placebo pill to see how it affects cortisol and other stress hormones. The goal was not to treat any disease, but to learn more about how GLP-1 drugs interact with the body's stress system. Part…
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC