Acute lung injury

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that often requires a breathing machine. This trial compares two ways of using that machine: airway pressure release ventilation (APRV), which holds the lungs open longer with brief releases, and convent…

This early-stage trial tests a new antibody called HT31-1 in 24 healthy volunteers to see if it is safe and how the body processes it. The antibody targets a protein linked to inflammation in acute respiratory distress syndrome (ARDS), a severe lung condition often caused by infe…

This study will test a new medical device kit (Novalung ultimate kit with Xenios 2.0) in 20 adult patients with severe heart-lung failure who need ECMO life support. The goal is to see if the device safely and effectively maintains blood oxygen levels during hospital use and grou…

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This study tests a drug called vadadustat in 1,100 hospitalized adults with acute respiratory distress syndrome (ARDS) caused by infection. Participants take either a low or high dose of vadadustat or a placebo daily for up to 14 days. The goal is to see if the drug reduces death…

This trial investigates whether placing infants with severe acute respiratory distress syndrome (ARDS) on their stomachs (prone positioning) after surfactant treatment can improve their oxygen levels. The study involves 14 mechanically ventilated infants, comparing oxygenation an…

This Phase 2 trial tests a drug called paridiprubart in hospitalized adults with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo as a single IV dose. The main goal is to see …

This study tests a medicine called vilobelimab in adults hospitalized with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and is safe…

This study tests a drug called bevacizumab in hospitalized adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and oxygen levels. The goal is to find a saf…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or an active drug to see if the treatments improve survival and are safe. The go…

This trial tests whether an antibody called IC14 can reduce dangerous lung inflammation in people with acute respiratory distress syndrome (ARDS), a severe condition where the lungs fill with fluid. Hospitalized patients on a ventilator receive either IC14 or a placebo, and resea…

This study tests whether using a lung imaging tool called EIT to set ventilator pressure (PEEP) can improve survival in patients with moderate-to-severe ARDS. The trial will enroll 2400 adults and compare EIT-guided PEEP to the standard method. The main goal is to see if this app…

This study tests whether a personalized ventilation strategy guided by electrical impedance tomography (EIT) can improve survival in adults with acute respiratory distress syndrome (ARDS). About 574 participants will be randomly assigned to receive either EIT-guided ventilation (…

This trial tests a real-time algorithm-driven system that gives doctors feedback on ventilator settings to protect the lungs of critically ill patients. The study will include 208 adults on breathing machines with acute respiratory distress syndrome (ARDS). The goal is to see if …

This early-phase trial tests a single inhaled dose of a lab-made protein (Rh-KGF-2) in 24 adults with moderate to severe ARDS who are on ventilators. The goal is to see if the drug is safe and tolerable, and to find the right dose. Participants are split into three dose groups, w…

This study tests whether Maraviroc, a drug already approved for HIV, can prevent a serious lung injury called primary graft dysfunction (PGD) after a lung transplant. PGD is a major cause of death in the first year after transplant, and there are no approved treatments for it. Ab…

This study tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with acute lung injury caused by sepsis. Sepsis triggers severe inflammation that often damages the lungs, and current treatments are limited. The trial will compare standard care plus …

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether an AI tool called LuAna helps doctors find lung problems in chest X-rays more accurately than doctors working alone. About 1,470 adults with breathing issues will have their X-rays read first by doctors, then with AI support. The goal is to see if AI boos…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study explores whether measuring the natural variability in a person's breathing can help predict complications after lung surgery. Researchers will use a sensor belt to continuously monitor chest movements in patients undergoing lung resection, both before anesthesia and af…

This study aims to build a digital early-warning system that uses machine learning to predict acute lung injury (ALI) in patients undergoing major liver surgery. By analyzing cardiopulmonary interaction characteristics, the model could help doctors identify at-risk patients early…

This study tests a special method of removing the breathing tube after abdominal surgery to prevent lung problems. It involves 270 adults at moderate or high risk of lung complications. The goal is to see if a protective extubation approach is practical and followed correctly by …

This study compares three ways to image the lungs of infants: CT scans, electrical impedance tomography (EIT), and lung ultrasound. The goal is to see how well the non-invasive methods (EIT and ultrasound) match up with CT in detecting collapsed or overinflated lung areas. Ten in…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study looks at two different methods for setting the pressure on a breathing machine (ventilator) in people with a serious lung condition called ARDS. The goal is to see which method improves oxygen levels better over 24 hours. About 52 adults with moderate to severe ARDS wi…

This study looks at blood from people with ARDS, a severe lung condition with no specific medicines. Researchers will take immune cells from the blood and test a new blocking agent in the lab to see if it can reduce lung damage. The goal is to learn more about the disease and fin…

This study tests whether a simple manual chest compression technique works as well as electrical impedance tomography (a special imaging method) to find the best ventilator pressure for people with acute respiratory distress syndrome (ARDS). Thirty adults on ventilators will have…

This study follows 150 older adults who survived a stay in the intensive care unit (ICU) for sepsis or lung injury. Researchers will measure muscle strength and physical function at hospital discharge and again at 3, 6, 12, and 24 months later. A small group will also have muscle…

This study looks at why some infants develop lung injury after heart surgery that uses a heart-lung machine. Researchers will collect blood and fluid from the lungs of 56 babies under 1 year old to study how their immune cells (neutrophils) behave. The goal is to better understan…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study tests a computer program that gives doctors step-by-step advice on how to set breathing machines for children with acute respiratory distress syndrome (ARDS). The goal is to see if the tool can be used in multiple hospitals and if doctors follow its recommendations. Up…

This study looks at why some people with a brain bleed (subarachnoid hemorrhage) develop lung injury. Researchers will measure hyaluronic acid and inflammation markers in lung fluid and blood from 24 patients. The goal is to understand the link and find better ways to diagnose an…

This study will use a 3D electrical impedance tomography (EIT) device to monitor how lung ventilation and blood flow change when ARDS patients are placed on their stomach (prone position). Researchers will track 30 patients on mechanical ventilation at three time points: lying on…

This observational study tracks 200 adults with severe burns (over 30% of body surface) to see if giving albumin in the first 24 hours after injury improves outcomes. Researchers will measure death rates, kidney failure, and severe lung problems within 28 days. The goal is to gat…

This study observes 134 adults having chest surgery to see if the time spent breathing with only one lung is linked to lung problems like pneumonia or ARDS. Researchers will track surgery details and check for complications within the first week after the procedure. The goal is t…

This study tracks complications from a lung-opening procedure used in children under 14 with acute respiratory distress syndrome (ARDS) who are on a breathing machine. The procedure, called alveolar opening maneuver with PEEP titration, aims to improve oxygen levels but can cause…

This study looks at whether closely tracking a patient's breathing effort can help doctors decide the best time to remove a life-support machine called ECMO in people with severe lung failure (ARDS). About 50 adults on ECMO will be randomly assigned to have their breathing monito…

This study will observe 500 people with Acute Respiratory Distress Syndrome (ARDS) in intensive care to understand what factors influence their recovery and survival. Researchers will track deaths, imaging, lab tests, and ventilator use. The goal is to find patterns that could im…