Can immunotherapy wipe out stomach cancer before surgery?

NCT ID NCT06250036

Terminated ⭐️ CURE ⭐️ Sponsor: Royal Marsden NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests whether giving immunotherapy drugs before surgery can completely eliminate tumors in patients with a specific type of stomach or gastro-esophageal junction cancer that has a high number of genetic mutations. Participants will receive either one drug (zimberelimab) or a combination of two drugs (zimberelimab plus domvanalimab) before undergoing surgery. The main goal is to see how often the cancer completely disappears after this treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Immunotherapy drugs zimberelimab (PD-1 inhibitor) and domvanalimab (TIGIT inhibitor)
What this could lead to: If successful, this could lead to a new treatment approach that eliminates gastric cancer before surgery, potentially improving cure rates.
What could go wrong: This is an early-phase trial with a small number of patients. The drugs may not work as hoped, and there are risks of immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for GASTRO-OESOPHAGEAL JUNCTIONAL ADENOCARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED GASTRIC ADENOCARCINOMA MSI-H/DMMR GASTRIC CANCER MSI-H/DMMR GASTROESOPHAGEAL-JUNCTION CANCER

Contacts and locations

Locations

Addenbrooke's Hospital

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Guy's and St Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Kent & Canterbury Hospital

Canterbury, Kent, CT1 3NG, United Kingdom
Ninewells hospital and Medical School

Dundee, DD1 9SY, United Kingdom
Royal Devon University Healthcare Foundation Trust

Exeter, Devon, EX2 5DW, United Kingdom
St Bartholomew's Hospital

London, EC1A 7BE, United Kingdom
St James's University hospital

Leeds, Yorkshire, LS9 7TF, United Kingdom
The Royal Free NHS Foundation Trust

London, NW32QG, United Kingdom
The Royal Marsden NHSFT

London, SW3 6JJ, United Kingdom
University College London Hospital NHS Foundation Trust

London, N15 6UL, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.