Arterial chemo combo shows promise in stomach cancer trial

NCT ID NCT05593458

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether giving chemotherapy directly into the artery (instead of through a vein) along with immunotherapy can better shrink locally advanced stomach cancer before surgery. About 190 participants will receive either the standard chemo regimen or the arterial infusion approach, followed by surgery and additional treatment. The study aims to see if the new method leads to higher rates of tumor clearance and better long-term survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Oxaliplatin, S-1, and Sintilimab (PD-1 antibody)
What this could lead to
If this works, it could offer a more effective way to shrink gastric tumors before surgery, potentially improving survival and reducing recurrence.
What could go wrong
This is a mid-stage trial with only 190 participants, so results may not apply to everyone. Arterial infusion carries risks like bleeding or infection, and the added benefit over standard therapy is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Gastrointestinal Department of Second Affiliated Hospital of Zhejiang University

    RECRUITING

    Hangzhou, Zhejiang, 310000, China

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