New pill combo aims to ease stubborn shingles nerve pain

NCT ID NCT07275762

Recruiting now Symptom relief Sponsor: Neurodawn Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new tablet called Y-4, which combines two drugs (pregabalin and riluzole), can better relieve postherpetic neuralgia—persistent nerve pain after shingles—compared to pregabalin alone. About 160 adults in China will take either Y-4 or pregabalin for 14 weeks. Researchers will track pain scores and side effects to see if the combination is more effective and safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Y-4 (a combination of pregabalin and riluzole)
What this could lead to: If it works, Y-4 could offer better pain relief for people with lingering nerve pain after shingles.
What could go wrong: This is an early Phase 2 trial with only 160 participants, so results may not apply to everyone. The added riluzole may cause side effects without improving pain control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Neuralgia, Postherpetic postherpetic neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTHERPETIC NEURALGIA PREGABALIN Y-4

Contacts and locations

Locations

Hospital for Skin Diseases, Chinese Academy of Medical Sciences
RECRUITING

Nanjing, Jiangsu, China

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