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Can tailoring bypass length improve weight loss surgery results?

NCT ID NCT04841057

Disease control Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are studying how the length of bypassed intestine during gastric bypass affects weight loss, complications, and metabolic changes in people with severe obesity. Participants will have different lengths of intestine bypassed and will provide blood and stool samples before and after surgery. The study also includes control groups having sleeve gastrectomy or non-surgical weight loss therapy. The goal is to understand how malabsorption and molecular changes influence outcomes and to move toward personalized weight loss surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gastric bypass surgery with different lengths of bypassed intestine
What this could lead to
If it works, doctors could tailor the length of bypassed intestine during gastric bypass to each patient, potentially improving weight loss and metabolic health.
What could go wrong
This is an early study, and the optimal limb length is unknown. Surgery carries risks such as infection, bleeding, and nutritional deficiencies, and the metabolic measurements may not translate into better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2021

Expected to finish

Mar 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age greater than 18 2. Body mass index of 40-60 kg/m2 3. Meet insurance criteria, as set forth by the patient's insurance policy, to qualify for coverage for weight loss surgery 4. Planned laparoscopic Roux-en-Y gastric bypass 5. Willingness to have blood collected before and after surgical procedure at defined points and collect and mail stool sample before operation and at defined post-operative time points. Exclusion Criteria: 1. Age less than 18 2. Patient fails to fulfill insurance mandated criteria 3. Unwilling to be randomized to variable length to gastric bypass or unwilling to have blood collected or personally collect and mail in stool sample 4. Unwilling to follow-up at required postoperative visits

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease metabolic syndrome X morbid obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic syndrome NASH - nonalcoholic steatohepatitis Obesity, morbid

How to take part

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  1. The places running it

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  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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  3. A doctor treating you

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Contacts and locations

Locations

  • University of Missouri-Columbia

    Columbia, Missouri, 65203, United States

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