New drug combo takes aim at aggressive brain tumor

This study tested a drug called VAL-083, given alongside standard radiation therapy, for people newly diagnosed with an aggressive brain cancer called glioblastoma (GBM). It focused on patients whose tumors have a specific genetic feature (unmethylated MGMT) that makes them less likely to respond to the usual chemotherapy. The main goals were to find the safest and most effective dose of VAL-083 to use with radiation and to see how well the treatment worked.