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A quick ultrasound in the ER: could it replace blood tests for blood clots?

NCT ID NCT04917328

Diagnosis Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial tests whether emergency doctors can use a bedside compression ultrasound to reliably rule out a deep vein thrombosis (DVT) in patients with low to moderate risk. Currently, a D-dimer blood test is the standard way to exclude DVT, but ultrasound might be faster and just as accurate. The study will enroll 700 adults with leg pain or swelling and a low Wells score, comparing the ultrasound's negative predictive value against the standard approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
compression ultrasound
What this could lead to
If effective, this could allow emergency doctors to quickly rule out deep vein thrombosis using ultrasound alone, reducing the need for blood tests and speeding up care.
What could go wrong
The trial is early and the accuracy of ultrasound depends on the doctor's skill. It may not be as reliable as the current D-dimer blood test, and false negatives could be missed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 700 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2022

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patient * Patient presenting to the emergency department with clinical suspicion of DVT (i.e. pain and/or lower extremity edema). * Patient with a non-high probability according to the modified Wells score, i.e. a score of 0 or 1 * Subject with a social health insurance plan * Subject able to understand the objectives and risks of the research and to give a signed and dated informed consent Exclusion Criteria: * Patient with suspected pulmonary embolism * Patient with a high probability of DVT * Impossible to perform a whole leg doppler ultrasound within 5 days * Pregnant or breast-feeding woman, on patient's declaration * Subject under court protection * Subject under guardianship or curatorship

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Conditions

The condition(s) this trial relates to.

venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep vein thrombosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Strasbourg

    RECRUITING

    Strasbourg, France

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