Brain zaps and online therapy: a new combo for depression?

NCT ID NCT05988619

Completed Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding internet-based cognitive behavioral therapy (iCBT) to transcranial magnetic stimulation (TMS) helps people with major depression more than TMS alone. Forty adults receiving TMS at UCLA also completed online therapy modules. Researchers measured changes in depression symptoms using several questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS) and Internet-Based Cognitive Behavioral Therapy (iCBT)
What this could lead to: If this works, it could point toward a more effective and convenient treatment for depression by combining brain stimulation with online therapy.
What could go wrong: This is a small, early-stage study with only 40 participants, so results may not apply to everyone. The added benefit of online therapy over TMS alone is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

UCLA TMS Clinical and Research Service

Los Angeles, California, 90024, United States

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