New drug combo shows promise for Tough-to-Treat Ewing's sarcoma

NCT ID NCT05046314

Completed Disease control Sponsor: Shanghai Pharmaceuticals Holding Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tested a new drug called TK216 combined with the chemotherapy drug vincristine in 15 people with Ewing's sarcoma that had come back or stopped responding to treatment. The main goal was to see how many patients' tumors shrank or disappeared. The study was completed in China and aimed to find a better option for this rare cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TK216 (a drug) combined with vincristine (a chemotherapy drug)
What this could lead to: If successful, this could point toward a new treatment option for people with Ewing's sarcoma that has come back or not responded to other therapies.
What could go wrong: This is a small, early-phase trial with only 15 participants, so results may not apply to everyone. The drug combination may cause side effects, and it is not yet known if it works better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARCOMA, EWING

Contacts and locations

Locations

Henan Cancer Hospital

Zhengzhou, Henan, 450003, China
Henan Provincial People's Hospital

Zhengzhou, Henan, 450003, China
Hunan Cancer Hospital

Changsha, Hunan, 410031, China
Peking University People's Hospital

Beijing, Beijing Municipality, 100044, China
Shanghai Sixth People's Hospital

Shanghai, Shanghai Municipality, 200233, China
The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310003, China
Tianjin Medical University Cancer Institude & Hospital

Tianjin, Tianjin Municipality, 300060, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 100005, China

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