Could a stem cell transplant tame Hard-to-Control MS?
NCT ID NCT04047628
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a stem cell transplant (using a person's own cells) against the best available medications for people with relapsing multiple sclerosis that hasn't responded to treatment. About 156 participants will be randomly assigned to one of the two approaches and followed for six years. The goal is to see if the transplant can better prevent relapses and slow disease progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
autologous hematopoietic stem cell transplant (AHSCT)
What this could lead to
If this works, it could offer a more effective way to control multiple sclerosis in people who haven't responded to standard treatments, potentially reducing relapses and disease activity.
What could go wrong
This is an advanced phase 3 trial, but the transplant procedure carries serious risks like infection and organ damage. It's also not a cure, and some participants may still have disease activity or need ongoing medication.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RELAPSING - REMITTING MULTIPLE SCLEROSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Clinical Research Division, Fred Hutchinson Cancer Research Center
RECRUITINGSeattle, Washington, 98109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Siinai
RECRUITINGNew York, New York, 10029, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Duke University Medical Center
ACTIVE_NOT_RECRUITINGDurham, North Carolina, 27710, United States
-
John L. Trotter Multiple Sclerosis Center, Washington University School of Medicine in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Maxine Mesigner Multiple Sclerosis Comprehensive Care Center, Baylor College of Medicine Medical Center
RECRUITINGHouston, Texas, 77030, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Multiple Sclerosis Center at Northwest Hospital
RECRUITINGSeattle, Washington, 98133, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Multiple Sclerosis Center, Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Multiple Sclerosis Center, Swedish Neuroscience Institute
RECRUITINGSeattle, Washington, 98122, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Northwestern University
RECRUITINGEvanston, Illinois, 60208, United States
Contact
Contact
Contact Email: •••••@•••••
-
Penn Comprehensive MS Center, Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Rochester Multiple Sclerosis Center, University of Rochester
NOT_YET_RECRUITINGRochester, New York, 14620, United States
Contact
-
Rocky Mountain Multiple Sclerosis Center, University of Colorado School of Medicine
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Stanford Multiple Sclerosis Center
RECRUITINGPalo Alto, California, 94304, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Cincinnati (UC) Waddell Center for Multiple Sclerosis
RECRUITINGCincinnati, Ohio, 45219, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Massachusetts Memorial Medical Center
RECRUITINGWorcester, Massachusetts, 01655, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Minnesota Multiple Sclerosis Center
ACTIVE_NOT_RECRUITINGMinneapolis, Minnesota, 55455, United States
-
University of Texas Southwestern Medical Center: Division of Multiple Sclerosis and Neuroimmunology
RECRUITINGDallas, Texas, 75390, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Virginia Commonwealth University Multiple Sclerosis Treatment and Research Center
RECRUITINGRichmond, Virginia, 23219, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact