Could a stem cell transplant tame Hard-to-Control MS?

NCT ID NCT04047628

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a stem cell transplant (using a person's own cells) against the best available medications for people with relapsing multiple sclerosis that hasn't responded to treatment. About 156 participants will be randomly assigned to one of the two approaches and followed for six years. The goal is to see if the transplant can better prevent relapses and slow disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: autologous hematopoietic stem cell transplant (AHSCT)
What this could lead to: If this works, it could offer a more effective way to control multiple sclerosis in people who haven't responded to standard treatments, potentially reducing relapses and disease activity.
What could go wrong: This is an advanced phase 3 trial, but the transplant procedure carries serious risks like infection and organ damage. It's also not a cure, and some participants may still have disease activity or need ongoing medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSING MULTIPLE SCLEROSIS RELAPSING-REMITTING MULTIPLE SCLEROSIS SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS

Contacts and locations

Show contact details

Locations

Clinical Research Division, Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Siinai
RECRUITING

New York, New York, 10029, United States
Duke University Medical Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
John L. Trotter Multiple Sclerosis Center, Washington University School of Medicine in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
Maxine Mesigner Multiple Sclerosis Comprehensive Care Center, Baylor College of Medicine Medical Center
RECRUITING

Houston, Texas, 77030, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Multiple Sclerosis Center at Northwest Hospital
RECRUITING

Seattle, Washington, 98133, United States
Multiple Sclerosis Center, Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Multiple Sclerosis Center, Swedish Neuroscience Institute
RECRUITING

Seattle, Washington, 98122, United States
Northwestern University
RECRUITING

Evanston, Illinois, 60208, United States
Penn Comprehensive MS Center, Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Rochester Multiple Sclerosis Center, University of Rochester
NOT_YET_RECRUITING

Rochester, New York, 14620, United States
Rocky Mountain Multiple Sclerosis Center, University of Colorado School of Medicine
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••
Stanford Multiple Sclerosis Center
RECRUITING

Palo Alto, California, 94304, United States
University of Cincinnati (UC) Waddell Center for Multiple Sclerosis
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Massachusetts Memorial Medical Center
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Minnesota Multiple Sclerosis Center
ACTIVE_NOT_RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Texas Southwestern Medical Center: Division of Multiple Sclerosis and Neuroimmunology
RECRUITING

Dallas, Texas, 75390, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Virginia Commonwealth University Multiple Sclerosis Treatment and Research Center
RECRUITING

Richmond, Virginia, 23219, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.