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A nose nerve block may cut children's throat surgery pain and opioid use

NCT ID NCT07793617

Symptom relief Sponsor: Vinícius C Quintão, MD, MSc, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial tests whether a sphenopalatine ganglion block, a numbing treatment placed in the nose, reduces pain after tonsil surgery in children aged 2 to 13. Each child receives either the block with a local anesthetic or a placebo, and researchers compare pain scores, painkiller use, nausea, and bleeding. The block is given under general anesthesia before surgery starts, using a cotton-tipped applicator soaked in the study solution.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A sphenopalatine ganglion block using ropivacaine, a local anesthetic, applied via a cotton-tipped applicator in the nostrils during surgery.
What this could lead to
If it works, this could give children a safer, drug-sparing way to manage throat surgery pain, reducing the need for opioids and their side effects.
What could go wrong
This is a single-center trial, and the block may not reduce pain enough to matter. There is also a small risk of bleeding or discomfort from placing the applicator.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 145 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 13 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 2 to 13 years admitted for tonsillectomy/tonsillotomy with or without adenoidectomy; * Patients classified as Physical Status I and II according to the American Society of Anesthesiologists (ASA); * Otolaryngologists responsible for the patient according to the study and willing to report the data necessary for this study. Exclusion Criteria: * Children with hypersensitivity or allergy to the drugs used in the study protocol for AG and/or BGEP; * Use of concomitant medications for anesthesia or pain control that are not in the study protocol in the pre or intraoperative period; * Children with a history of chronic orofacial pain; * Failure to provide written Informed Consent Form (ICF) or Informed Assent form (IAF) to participate in the study.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adenotonsillectomy Postoperative pain Tonsillectomy

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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