Could shorter antibiotic courses be safer for ventilator pneumonia?

NCT ID NCT05545735

Terminated Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving antibiotics for 4 days instead of the usual 7 days is safe and effective for patients with ventilator-associated pneumonia (VAP). The goal was to reduce side effects from antibiotics while still treating the infection. The trial was stopped early after enrolling only 27 surgical patients, so the findings are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics
What this could lead to: If successful, this could show that a shorter course of antibiotics is safe and effective for early ventilator-associated pneumonia, reducing side effects and antibiotic resistance.
What could go wrong: The trial was terminated early with only 27 participants, so results are limited and may not be reliable. Shorter treatment might not clear the infection in all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTILATOR ASSOCIATED PNEUMONIA

Contacts and locations

Locations

Jackson Memorial Hospital

Miami, Florida, 33136, United States

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