Can an amino acid boost chemo? early trial launches for advanced colorectal cancer

NCT ID NCT07178613

Not yet recruiting Disease control Sponsor: The First Affiliated Hospital of Xinxiang Medical College Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This early-stage trial is testing whether adding oral serine, a natural amino acid, to standard chemotherapy is safe for people with advanced colorectal cancer. The study will enroll 20 adults who are eligible for first-line treatment with fluorouracil-based drugs. The main goal is to check for side effects and find the best dose of serine to use in future studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: serine (an amino acid) taken orally alongside standard chemotherapy drugs (fluoropyrimidines)
What this could lead to: If successful, this could point toward a way to make standard chemotherapy more effective or less toxic for people with advanced colorectal cancer.
What could go wrong: This is a very early Phase 1 trial with only 20 people. The main goal is safety, not yet proof that it works. It may not show any benefit or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED COLORECTAL CANCER

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Other studies related to the condition(s) this trial covers.