Could a diabetes drug sharpen your mind?
NCT ID NCT04466345
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether semaglutide, a drug used for diabetes, can improve cognitive function in people with major depressive disorder. 72 overweight adults with below-average thinking speed took either semaglutide or a placebo for 16 weeks. Researchers measured changes in executive function, memory, and attention.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
semaglutide
What this could lead to
If it works, this could point toward a new way to help with thinking and memory problems in people with depression.
What could go wrong
This is a small, early-phase study. The results may not apply to everyone, and semaglutide can cause side effects like nausea or stomach issues.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Toronto Western Hospital
Toronto, Ontario, M5T 2S8, Canada