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Could fewer files mean less pain after root canals?

NCT ID NCT07091981

Disease control Sponsor: Mehmet Adıgüzel Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Sep 09, 2026 · Updated 3 times

Summary

This trial compares root canal treatments using one, two, three, or four rotary files to see if the number of instruments affects how well dentists can reach a tricky second canal in upper molars and how much pain patients feel afterward. Adults with asymptomatic apical periodontitis in a maxillary first molar will be randomly assigned to one of the four file systems. Pain is measured daily for a week after the procedure, and success in reaching the full canal length is recorded during treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rotary endodontic files (single-, two-, three-, or four-file systems) used during root canal treatment
What this could lead to
If fewer files work as well or better, dentists might adopt simpler, faster root canal procedures that cause less post-treatment discomfort.
What could go wrong
This is a small, early-stage trial, and results may not apply to all patients or tooth types. Pain is subjective, and the number of files may not be the only factor influencing outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

168 people

The number who actually took part.

Started

Jul 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy individuals aged between 20 and 65 years * Requiring primary endodontic treatment of maxillary first molars * Diagnosis of asymptomatic apical periodontitis based on clinical and radiographic findings * Presence of a second mesiobuccal (MB2) canal in the maxillary first molar * Absence of preoperative pain or symptoms * Teeth with periapical lesions smaller than 5 mm in diameter * Ability to comply with follow-up visits and effectively communicate during the treatment process Exclusion Criteria: * Presence of symptomatic apical periodontitis or acute apical abscess * Need for retreatment of previously treated teeth * Use of medications such as narcotics, antibiotics, sedatives, or antidepressants within one week prior to treatment * Presence of a sinus tract, periapical abscess, or facial cellulitis * Pregnancy * Inability to understand or follow the study instructions

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic apical periodontitis Postoperative pain

Contacts and locations

Locations

  • Hatay Mustafa Kemal University Faculty of Dentistry

    Antakya, Hatay, 31006, Turkey (Türkiye)

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