Which graft works best for Second-Time ACL surgery?

NCT ID NCT07671235

Recruiting now Knowledge-focused Sponsor: Stefano Zaffagnini Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This study looks at 150 people needing a second ACL reconstruction after the first graft failed. Researchers will compare outcomes between using a graft from the patient's own body (autograft) versus a donor graft (allograft). The goal is to see which option leads to fewer failures and better knee function over at least two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allograft or autograft (tissue graft used in knee surgery)
What this could lead to: If successful, this study could help surgeons choose the best graft type for revision ACL surgery, potentially reducing re-rupture rates and improving long-term knee health.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients, and the follow-up period is limited.

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACL INJURY GRAFT FAILURE

Contacts and locations

Locations

IRCCS Rizzoli Orthopedic Institute
RECRUITING

Bologna, Bologna, 40136, Italy

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