Tracking blood markers over time may reveal hidden heart risk
NCT ID NCT07817576
First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time
Summary
Researchers at University Hospital Freiburg are studying how blood levels of hsCRP and Lp(a), two markers linked to heart disease, change over time in patients who have had these tests more than once. The study asks whether a high result on a first test often returns to normal later, and whether patients whose levels stay high across repeated tests face a higher risk of death than those whose high level was temporary. The study uses existing medical records and death registry data from about 110,000 participants.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If repeated testing proves more informative, doctors could use serial biomarker patterns to spot patients at higher risk and tailor monitoring or treatment.
- What could go wrong
- This observational study cannot prove that biomarker changes cause worse outcomes, and results may not apply to people who have not had these tests.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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110,000 people
The number who actually took part.
- Started
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Jan 2004
- Expected to finish
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Jan 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Agnostic design. All-comers cohort at the University Hospital Freiburg, Department of Cardiology. Locations Freiburg and Bad-Krozingen
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- Available Biomarker Measurement Exclusion Criteria: \- \< 18 years, Biomarker not available
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Cardiology - Freiburg - Bad Krozingen
Freiburg im Breisgau, Germany
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