Surgery before chemo for advanced rectal cancer? small trial offers few answers
NCT ID NCT02314182
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether removing the primary rectal tumor before starting chemotherapy helps people with rectal cancer that has spread to other organs (but cannot be cured) live longer. Only 5 people took part, and the trial was completed early. The results are too limited to draw firm conclusions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Primary tumor resection followed by chemotherapy
- What this could lead to
- If successful, this could show that removing the main tumor before chemotherapy helps people with advanced rectal cancer live longer.
- What could go wrong
- This was a very small trial (only 5 participants) and was completed early, so results are not reliable. The approach may not improve survival and surgery carries risks like infection or complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Service d'Oncologie Médicale, Clinique du Cap-d'Or
La Seyne-sur-Mer, 83500, France
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Service de Chirurgie Générale et Digestive, CHRU Claude Huriez
Lille, 59067, France
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Service de Chirurgie Générale et Digestive, Centre hospitalier Lyon Sud, HCL
Pierre-Bénite, France, 69495, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can diet and vitamin c supercharge rectal cancer treatment?
- AI as a surgical Co-Pilot: predicting difficulty in rectal cancer
- A new radiation combo may spare the rectum in early cancer
- Can a triple-drug cocktail after short radiation eliminate rectal cancer without surgery?
- Metabolic MRI may reveal hidden cancer responses and spare patients from surgery
- Can a beetroot drink spot dangerous surgical leaks before they turn deadly?