Shorter radiation may be just as good for rectal cancer patients
NCT ID NCT07258797
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two standard radiotherapy approaches—short-course (1 week) and long-course (several weeks)—given before surgery to people with locally advanced rectal cancer. The goal is to see which one works better at shrinking tumors and is easier for patients to tolerate. About 150 participants will be randomly assigned to one of the two treatments, and their outcomes will be tracked.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiotherapy (short-course or long-course) plus chemotherapy (modified FOLFOX6 or mFOLFIRINOX)
- What this could lead to
- If successful, this study could show that a shorter radiotherapy course is just as effective as the longer one, potentially reducing treatment burden for patients with rectal cancer.
- What could go wrong
- This is a single-institution study with 150 participants, so results may not apply broadly. Both treatments are standard, so no major breakthrough is expected.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rajiv Gandhi Cancer Institute and Research Centre
New Delhi, 110085, India
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Immunotherapy before surgery shows promise for certain colorectal cancers
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- New study aims to Fine-Tune radiation for liver cancer spread
- Researchers track rectal cancer treatment responses