Precision radiation boost aims to tame High-Risk prostate cancer
NCT ID NCT05628363
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests a precise radiation technique called adaptive SBRT for men with high-risk or unfavorable intermediate-risk prostate cancer. The treatment targets the prostate and pelvic lymph nodes while giving an extra radiation boost to tumor spots seen on MRI. The goal is to see if this approach is safe and feasible, with fewer than 15% of the 28 participants experiencing severe urinary or bowel side effects within 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (SBRT) and androgen deprivation therapy (ADT)
- What this could lead to
- If successful, this approach could offer a more precise, shorter radiation course for high-risk prostate cancer, potentially reducing side effects while effectively targeting tumors.
- What could go wrong
- This is a small, early-phase trial (28 participants) focused on safety, not yet proving effectiveness. Side effects from radiation and ADT, such as urinary or bowel issues, are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CANCER OF THE PROSTATE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new tracer light up hidden prostate cancer?
- Could deep breaths before surgery ward off Post-Op confusion?
- A second look: MRI screening may spot hidden prostate cancers
- Can precision protons spare the bowel in prostate cancer?
- AI coaches doctors on cancer risk talks
- Can an immune booster make hormone therapy work better against prostate cancer?