Can a school program turn the tide on teen suicide?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Schools * Located in Santiago, Chile * Secondary school (1st through 4th year of secondary school) * At least two classes per grade level * At least 30 students per class * High vulnerability index (≥50%) as measured by the School Vulnerability Index - National Allocation System for Equality (IVE-SINAE) 2. Students * Students in grades 9, 10, and 11 * Suicidal ideation reported in the past month, defined as a score ≥3 on the Columbia Suicide Severity Rating Scale (C-SSRS) * For the Reframe-IT+ Program: mild or moderate depressive symptoms, defined as a score \<20 on the PHQ-9 * For the CARIBOU-CBT Program: severe depressive symptoms, defined as a score ≥20 on the PHQ-9 Exclusion Criteria: * Participation in a manualized suicide prevention program (Reframe-IT+/CARIBOU) in 2025 * Severe psychotic symptoms, defined as clear perceptual disturbances and delusions identified during the invitation interview * Suicide attempt(s) in the past 3 months, or active suicidal ideation requiring hospitalization, as determined during the screening interview * History of a prior medical diagnosis of Bipolar Disorder I or II * History of a prior medical diagnosis of a Severe Eating Disorder (e.g., Anorexia Nervosa or Bulimia) * Severe substance use disorder, meeting any of the following patterns: daily cannabis use throughout the day; excessive alcohol or benzodiazepine use ≥3 times per week; cocaine or opioid use several days per month or more, as determined during the screening interview * Intellectual disability * Inability to speak, read, or write in Spanish