Progesterone or pessary: which prevents preterm birth better?

NCT ID NCT02511574

Completed Prevention Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether natural progesterone or a cervical pessary (a silicone ring placed in the vagina) is better at preventing early birth in pregnant women with a short cervix (25 mm or less). The trial included 203 women with a single baby. Researchers tracked how many gave birth before 34 weeks. The goal is to find the most effective way to reduce preterm births and improve newborn health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: natural progesterone (drug) and cervical pessary (device)
What this could lead to: If one option proves clearly better, it could become the standard way to prevent preterm birth in women with a short cervix, reducing health risks for babies.
What could go wrong: This is a single completed study with 203 participants, so results may not apply to all pregnant women. Neither treatment is a guarantee, and some women may still deliver early.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obstetric Labor, Premature Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREMATURE BIRTH PRETERM LABOR

Contacts and locations

Locations

Hospital das Clínicas da Faculdade de Medicina da USP

São Paulo, São Paulo, 05403-000, Brazil

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