Light therapy may stop painful mouth sores in transplant patients
NCT ID NCT07290413
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests if shining a special light inside the mouth, outside the cheek, or both can prevent severe mouth sores in people getting a stem cell transplant. About 78 patients will receive daily light therapy during their transplant stay. The goal is to find the best way to reduce pain and help patients recover more comfortably.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 78 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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4 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Planned to undergo myeloablative allogeneic HCT (with one of the following regimens): FluBu4, FluMel, or CyTBI conditioning and Tac-Mtx GVHD prophylaxis * Age ≥4 years * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Participants who have had treatment with oral PBMT within four weeks of admission for HSCT. * Participants who have a history of radiation therapy to the head and neck. * Participants who have a history of photosensitivity or underlying disease with known photosensitivity. * Participants who are planned to receive palifermin (keratinocyte growth factor) for OM prevention. * Participants who have facial hair and unwilling to shave.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Systematic oral hygiene intervention for the prevention and control of oral mucositis in children undergoing hematopoietic stem cell transplantation during the perioperative period: a prospective, randomized controlled clinical trial
- Lactobacillus rhamnosus GG alleviates oral mucositis in patients undergoing radiotherapy for malignant head and neck tumors: a randomized controlled trial
- Randomized, Double-Blind, Placebo-Controlled phase II study to evaluate the efficacy of a Copaiba-Based mouthwash combined with Low-Level laser therapy in the prevention of oral mucositis in patients undergoing hematopoietic stem cell transplantation
- Impact of aloe vera mouthwash on the prevention and severity of oral mucositis in adults in with hematologic malignancies
- Olive oil and xylitol mouth rinse may shield cancer patients from painful mouth sores
- Can laser or ozone therapy better soothe cancer-related mouth pain? a head-to-head comparison