Root canal relief: preemptive pain pills tested
NCT ID NCT07400471
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving pain medicine before a root canal can lower pain during and after the procedure. 280 adults with moderate to severe tooth pain will receive either a combination of pregabalin and acetaminophen, duloxetine and acetaminophen, or a placebo before treatment. Researchers will measure pain levels at several time points to see which approach works best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pregabalin, Acetaminophen, Duloxetine
What this could lead to
If it works, this could lead to a simple way to make root canals less painful by taking medication beforehand.
What could go wrong
This is a very early, small trial. The drugs may not work better than placebo, and side effects like dizziness or drowsiness are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Professor. Dr. Md. Abu Saeed Ibn Harun
RECRUITINGChittagong, Chattogram, 4212, Bangladesh
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact