Root canal relief: preemptive pain pills tested
NCT ID NCT07400471
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving pain medicine before a root canal can lower pain during and after the procedure. 280 adults with moderate to severe tooth pain will receive either a combination of pregabalin and acetaminophen, duloxetine and acetaminophen, or a placebo before treatment. Researchers will measure pain levels at several time points to see which approach works best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pregabalin, Acetaminophen, Duloxetine
- What this could lead to
- If it works, this could lead to a simple way to make root canals less painful by taking medication beforehand.
- What could go wrong
- This is a very early, small trial. The drugs may not work better than placebo, and side effects like dizziness or drowsiness are possible.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Professor. Dr. Md. Abu Saeed Ibn Harun
RECRUITINGChittagong, Chattogram, 4212, Bangladesh
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