Heart study volunteers get their genetic secrets back

NCT ID NCT04196374

Completed Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study looked at how to return important genetic findings to people who had already had their genomes sequenced as part of two large heart studies. Researchers contacted 48 participants who had consented to receive results, offering them a chance to confirm and discuss any actionable genetic variants with their doctor. The goal was to understand how many people follow through, what it costs, and whether it leads to better medical care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Genomic Sequencing
What this could lead to: If successful, this could help develop efficient, scalable ways to return meaningful genetic results to large populations, potentially improving early detection and prevention of inherited diseases.
What could go wrong: This is a small, completed observational study focused on process and feasibility, not on proving health outcomes. The findings may not apply to other populations or healthcare settings.

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Conditions

The condition(s) this trial relates to.

inherited disease susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENETIC PREDISPOSITION TO DISEASE SEEMINGLY HEALTHY

Contacts and locations

Locations

Framingham Heart Study

Framingham, Massachusetts, 01702, United States
Jackson Heart Study

Jackson, Mississippi, 39213, United States

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