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Platelet injections face off against placebo for knee arthritis

NCT ID NCT03734900

NEW Symptom relief Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers compare two platelet-based injections, platelet lysate and platelet-rich plasma, against a saline placebo in adults aged 50 to 80 with mild to moderate knee osteoarthritis. Participants receive one injection into the knee and researchers track pain, joint function, X-ray and ultrasound changes, and side effects. The goal is to see whether either platelet treatment eases symptoms better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
autologous platelet lysate and platelet-rich plasma injections
What this could lead to
If platelet lysate or PRP outperforms placebo, it could offer a nonsurgical option to ease knee osteoarthritis pain and improve joint function.
What could go wrong
Knee injections can cause temporary pain, swelling, or infection, and results may not last. Platelet therapies may not beat placebo, and this single trial cannot prove long-term benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2018

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 50 to 80 years old * Study Subjects must be willing to sign Informed Consent to participate in the study * In the past month, at least seven consecutive days in the squat, standing, walking or going up and down the stairs, the most serious degree of visual analogy of the knee pain (Visual Analogue Scale) is greater than or equal to 40 (the most pain is 100, not painful is 0) * Morning joint stiffness is less than 30 minutes * X-ray：Grade 1-3 radiographic OA as defined by the K-L classification Exclusion Criteria: * Knee instability * The knee joint is obviously deformed (\> 5 degree valgus or varus deviation on X-ray) * Clinical diagnosed as Pes tendinitis, Chondromalacia * Taking NSAIDs or steroids (including oral and injection) within one week * Using anticoagulant drugs for a long time * Platelet count is less than 150,000 / UL, or coagulation disorders, prothrombin time (PT value) is less than 11 seconds or greater than 16 seconds * Leukemia, sepsis, platelet dysfunction or other blood related diseases * tumors, infections or the trauma before the same site * Pregnancy

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis (OA) of the knee

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100, Taiwan

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