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Light weights, tight cuff: a new way to prep knees for surgery?

NCT ID NCT06964022

Disease control Sponsor: University Hospital, Bonn Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether blood-flow-restriction (BFR) training, done before knee replacement surgery, can reduce pain and boost strength. BFR uses a cuff to partially block blood flow during low-weight exercise, which may build muscle without heavy loads. About 19 people scheduled for knee replacement will do a six-week exercise program with either real BFR or a sham version. Researchers will measure pain and muscle strength before and after surgery to see if this training helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood-flow-restriction (BFR) training, a method where a cuff partially blocks blood flow during low-weight exercise
What this could lead to
If it works, this approach could offer a way for people awaiting knee replacement to build strength and reduce pain without heavy weights, potentially improving recovery after surgery.
What could go wrong
This is a small early trial with only 19 participants, so results may not apply broadly. The cuff pressure must be carefully set to avoid discomfort or injury, and people with certain vascular conditions cannot take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

19 people

The number who actually took part.

Started

Jan 2023

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Indication for TKA Surgery * Ability to perform prehabilitation exercise Exclusion Criteria: * Sickle Cell Anemia * Iatrogenic changes in the vessels of the lower extremities (e.g. stents) * Open wounds/Infection of the lower extremities

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis (OA) of the knee

Contacts and locations

Locations

  • University Hospital Bonn

    Bonn, North Rhine-Westphalia, 53127, Germany

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