New drug combo shows promise in shrinking melanoma before surgery

NCT ID NCT04207086

First seen Jan 11, 2026 · Last updated May 07, 2026 · Updated 18 times

Summary

This study tests whether giving two drugs, pembrolizumab and lenvatinib, before surgery can help shrink tumors in people with stage III melanoma that can be removed. About 21 adults with resectable stage III melanoma will receive the drugs for 6 weeks, then have surgery to remove any remaining tumor. The main goal is to see how many patients have no cancer cells left in the removed tissue, and to understand how the drugs affect the immune system.

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Contacts and locations

Locations

  • Melanoma Institute Australia

    North Sydney, New South Wales, 2060, Australia

Conditions

Explore the condition pages connected to this study.