New hope for teens with MS: drug trial aims to cut relapses
NCT ID NCT03958877
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a drug called BIIB017 (Plegridy) in teenagers aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). It compares Plegridy to another MS drug, Avonex, to see which is safer and more effective at reducing relapses. The trial involves 152 participants and includes a long-term follow-up to monitor side effects and disease outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Peginterferon beta-1a (Plegridy)
What this could lead to
If successful, this could provide a new treatment option for teenagers with relapsing-remitting MS, potentially reducing relapses and slowing disease progression.
What could go wrong
This is an early-stage Phase 3 trial with only 152 participants, so results may not apply to all patients. Side effects from interferons can include flu-like symptoms and injection site reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Akdeniz University Medical Faculty
Antalya, 07059, Turkey (Türkiye)
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Azienda Ospedaliera Universitaria 'Federico II'
Naples, 80131, Italy
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Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli"
Naples, 80138, Italy
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Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer
Florence, 50139, Italy
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CHU Strasbourg - Hôpital Hautepierre
Strasbourg, Bas Rhin, 67098, France
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Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António
Porto, 4099-001, Portugal
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Centro Hospitalar e Universitário Lisboa Norte E.P.E.
Lisbon, Lisbon District, 1649-035, Portugal
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Centro Hospitalar e Universitário de Coimbra E.P.E. - Hospital Pediátrico
Coimbra, 3000-602, Portugal
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Charité - Campus Virchow-Klinikum
Berlin, 13353, Germany
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Children's Hospital Zagreb
Zagreb, 10000, Croatia
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Clinic of Neurology and Psychiatry for Children and Youth
Belgrade, Balkans, 11000, Serbia
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Clinical Hospital Center 'Sestre Milosrdnice'
Zagreb, 10000, Croatia
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Clinique CHC MontLégia
Liège, Wallonia, 4000, Belgium
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Debreceni Egyetem
Debrecen, Hajdú-Bihar, 4032, Hungary
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FSBI "Federal Siberian Scientific-Clinical Center of FMBA"
Krasnoyarsk, Krasnoyarsk Krai, 660037, Russia
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Fakultni nemocnice Hradec Kralove
Hradec Králové, 50333, Czechia
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Gazi University Medical Faculty Clinical Research Unit
Ankara, 06500, Turkey (Türkiye)
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General Hospital of Larissa
Larissa, Thessaly, 41110, Greece
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General Hospital of Thessaloniki 'Hippokration'
Thessaloniki, 54642, Greece
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Hadassah University Hospital - Ein Kerem
Jerusalem, Levant, 9112001, Israel
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Hopital Gui de Chauliac
Montpellier, Herault, 34295, France
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Hopital Purpan
Toulouse, Haute Garonne, 31059, France
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Hopital Razi
Manouba, Mannouba, 2010, Tunisia
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Hopital Roger Salengro - CHU Lille
Lille, Nord, 59037, France
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Hospital Beatriz Ângelo
Loures, Lisbon District, 2674-514, Portugal
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Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, Buenos Aires, 1199, Argentina
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Hospital Sant Joan de Deu
Esplugues de Llobregat, Barcelona, 08950, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14011, Spain
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Hospital Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120, Spain
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Hospital de Braga
Braga, Minho, 4710-243, Portugal
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Hôpital Bicêtre
Le Kremlin-Bicêtre, Val De Marne, 94275, France
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Hôpital Fattouma Bourghiba
Monastir, 5000, Tunisia
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Hôpital Habib Bourguiba
Sfax, 3029, Tunisia
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Ibn Sina Hospital
Ash Shuwaykh, Shuwaikh, 12345, Kuwait
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Izmir Dr. Behcet Uz Cocuk Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi
Izmir, 35210, Turkey (Türkiye)
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King Faisal Specialist Hospital & Research Center
Jeddah, Mecca Region, 40047, Saudi Arabia
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King Saud University
Riyadh, 11461, Saudi Arabia
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LLC National center for socially significan disease
Saint Petersburg, Sankt-Peterburg, 197110, Russia
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MHATNP 'Sv.Naum', EAD
Sofia, 1113, Bulgaria
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Meridian Clinical Research
Norfolk, Virginia, 23502, United States
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Mother and Child Health Care Institute of Serbia ,,Dr Vukan Cupic''
Belgrade, Balkans, 11070, Serbia
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Narodny ustav detskych chorob
Bratislava, 83340, Slovakia
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Nebbiolo LLC
Tomsk, Oblast, 634009, Russia
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Ondokuz Mayis Univ. Med. Fac.
Samsun, 55139, Turkey (Türkiye)
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Pecsi Tudomanyegyetem KK
Pécs, Baranya, 7623, Hungary
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RSBIH 'Belgorod Regional Clinical Hospital of Saint Ioasaf'
Belgorod, 308007, Russia
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Royal Children's Hospital
Parkville, Victoria, 3052, Australia
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SAIH 'Kemerovo Regional Clinical Hospital'
Kemerovo, Siberia, 650066, Russia
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SBEI HPE 'Bashkir State Medical University' of the MoH of the RF
Ufa, Bashkortostan Republic, 450077, Russia
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SBEI HPE 'Rostov State Medical University' of the MoH of the RF
Rostov-on-Don, 344022, Russia
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SBHI
Moscow, 119602, Russia
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SBIH of Moscow region "Moscow Regional Scientific & Research
Moscow, 129110, Russia
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Schneider Children's Medical Center
Petach-Tikva, Tel Aviv, 4920235, Israel
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Semmelweis Egyetem
Budapest, 1083, Hungary
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St. Josef-Hospital Universitaetsklinikum
Bochum, North Rhine-Westphalia, 44791, Germany
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State Budgetary Institution of Healthcare of Yaroslavl region 'Clinical Hospital # 2'
Yaroslavl, 150000, Russia
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UC San Diego Health
La Jolla, California, 92024, United States
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UNC Hospitals
Chapel Hill, North Carolina, 27514, United States
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Universitaetsklinikum Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Universitaetsmedizin Goettingen
Göttingen, Lower Saxony, 37075, Germany
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Universitair Ziekenhuis Ghent
Ghent, East Flanders, 9000, Belgium
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University Children Hospital
Belgrade, Balkans, 11000, Serbia
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University Hospital Centre Split
Split, Dalmatia, 21000, Croatia
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University Hospital Centre Zagreb
Zagreb, 10000, Croatia